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English
Revealing atropisomer axial chirality in drug discovery
scientific article published on 05 January 2011
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
title
Revealing atropisomer axial chirality in drug discovery
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
main subject
drug discovery
1 reference
based on heuristic
inferred from title
author name string
Steven R LaPlante
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
Paul J Edwards
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
Lee D Fader
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
Araz Jakalian
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
Oliver Hucke
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
publication date
5 January 2011
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
published in
ChemMedChem
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
volume
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
issue
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
page(s)
505-513
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
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Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
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7 January 2021
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Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide.
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Putting chirality to work: the strategy of chiral switches
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7 January 2021
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The challenge of atropisomerism in drug discovery
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Crossref
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7 January 2021
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Dynamic kinetic resolution of biaryl atropisomers via peptide-catalyzed asymmetric bromination.
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7 January 2021
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Clearance of polychlorinated biphenyl atropisomers is enantioselective in female C57Bl/6 mice
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Concentrations and chiral signatures of polychlorinated biphenyls in outdoor and indoor air and soil in a major U.K. conurbation
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Stereoselective total synthesis of axially chiral natural products via biaryl lactones
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7 January 2021
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Controlling axial conformation in 2-arylpyridines and 1-arylisoquinolines: application to the asymmetric synthesis of QUINAP by dynamic thermodynamic resolution.
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7 January 2021
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Total and percent atropisomers of gossypol and gossypol-6-methyl ether in seeds from pima cottons and accessions of Gossypium barbadense L.
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7 January 2021
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Simulation of the impact of atropisomer interconversion on plasma exposure of atropisomers of an endothelin receptor antagonist
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Crossref
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7 January 2021
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Atropisomers and near-atropisomers: achieving stereoselectivity by exploiting the conformational preferences of aromatic amides
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7 January 2021
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Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.
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Specific ligand binding on genetic variants of human alpha1-acid glycoprotein studied by circular dichroism spectroscopy
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Competitive CYP2C9 inhibitors: enzyme inhibition studies, protein homology modeling, and three-dimensional quantitative structure-activity relationship analysis
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Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study.
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7 January 2021
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Treatment with laquinimod reduces development of active MRI lesions in relapsing MS.
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7 January 2021
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Synthesis and reactivity of laquinimod, a quinoline-3-carboxamide: intramolecular transfer of the enol proton to a nitrogen atom as a plausible mechanism for ketene formation
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Iomeprol: a review of its use as a contrast medium
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7 January 2021
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High-performance liquid chromatographic assay of the X-ray contrast agent iopiperidol in plasma and urine of rats and humans
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7 January 2021
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The chemistry of iomeprol and physico-chemical properties of its aqueous solutions and pharmaceutical formulations.
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7 January 2021
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Determination of afloqualone in human plasma using liquid chromatography/tandem mass spectrometry: Application to pharmacokinetic studies in humans
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7 January 2021
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Synthesis of the metabolites of afloqualone and related compounds
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7 January 2021
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Assessment of the stereoselective metabolism of methaqualone in man by capillary electrophoresis
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7 January 2021
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Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector
1 reference
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7 January 2021
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The anti-hepatitis drug DDB chemosensitizes multidrug resistant cancer cells in vitro and in vivo by inhibiting P-gp and enhancing apoptosis
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7 January 2021
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Identifiers
DOI
10.1002/CMDC.201000485
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
PubMed publication ID
21360821
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21360821
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21360821%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 January 2020
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