(Q83769770)

English

Interaction of wild type, G68R and L125M isoforms of the arylamine-N-acetyltransferase from Mycobacterium tuberculosis with isoniazid: a computational study on a new possible mechanism of resistance

scientific article published on 30 March 2012

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Interaction of wild type, G68R and L125M isoforms of the arylamine-N-acetyltransferase from Mycobacterium tuberculosis with isoniazid: a computational study on a new possible mechanism of resistance (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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Mycobacterium tuberculosis

1 reference

based on heuristic

inferred from title

Ricardo M Ramos

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Hermes Luís Neubauer de Amorim

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

author name string

Janaína Menezes Perez

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Luis André Baptista

3

1 reference

Europe PubMed Central

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27 January 2020

publication date

30 March 2012

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Europe PubMed Central

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27 January 2020

Journal of Molecular Modeling

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

18

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

4013-4024

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new method for predicting binding affinity in computer-aided drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational and expression analysis of tbnat and its response to isoniazid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand binding affinity prediction by linear interaction energy methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linear interaction energy (LIE) method in lead discovery and optimization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated docking of flexible ligands: applications of AutoDock

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Python: a programming language for software integration and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotyping human arylamine N-acetyltransferase type 1 (NAT1): the identification of two novel allelic variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoniazid preventive therapy and risk for resistant tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arylamine N-acetyltransferases: from structure to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of isoniazid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylation pharmacogenetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00894-012-1383-6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22460521%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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