(Q84106913)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

To differentiate or not--routes towards metastasis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Thomas Brabletz

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

publication date

11 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

425-436

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576165%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc3265

1 February 2020

exact match

0 references

cites work

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31 March 2020

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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

31 March 2020

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

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Generation of breast cancer stem cells through epithelial-mesenchymal transition

31 March 2020

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

31 March 2020

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Human tumor cell heterogeneity and metastasis

31 March 2020

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What factors influence survival in patients with unresected synchronous liver metastases after resection of colorectal cancer?

31 March 2020

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Systematic review of prognostic factors related to overall survival in patients with stage IV colorectal cancer and unresectable metastases

31 March 2020

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A perspective on cancer cell metastasis

31 March 2020

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A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

31 March 2020

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miR-200b mediates post-transcriptional repression of ZFHX1B.

31 March 2020

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

31 March 2020

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Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin

31 March 2020

1 reference

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

31 March 2020

1 reference

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

31 March 2020

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Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

31 March 2020

1 reference

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

31 March 2020

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Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells

31 March 2020

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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

31 March 2020

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The role of the ZEB family of transcription factors in development and disease.

31 March 2020

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The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?

31 March 2020

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Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition

31 March 2020

1 reference

EP300--a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas

31 March 2020

1 reference

MicroRNA expression profiles in serous ovarian carcinoma.

31 March 2020

1 reference

The microRNA-200 family is upregulated in endometrial carcinoma

31 March 2020

1 reference

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

31 March 2020

1 reference

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

31 March 2020

1 reference

Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines

31 March 2020

1 reference

Development and characterization of gemcitabine-resistant pancreatic tumor cells.

31 March 2020

1 reference

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

31 March 2020

1 reference

miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy

31 March 2020

1 reference

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

31 March 2020

1 reference

miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1

31 March 2020

1 reference

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.

31 March 2020

1 reference

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

31 March 2020

1 reference

Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas

31 March 2020

1 reference

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.

31 March 2020

1 reference

The miR-34 family in cancer and apoptosis

31 March 2020

1 reference

p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.

31 March 2020

1 reference

MiR-34, SIRT1 and p53: the feedback loop

31 March 2020

1 reference

Blinded by the Light: The Growing Complexity of p53

31 March 2020

1 reference

The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation

31 March 2020

1 reference

p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors

31 March 2020

1 reference

Circulating tumor cells and bone marrow micrometastasis

31 March 2020

1 reference

Controversies in clinical cancer dormancy

31 March 2020

1 reference

Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions

31 March 2020

1 reference

Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway

31 March 2020

1 reference

Snail blocks the cell cycle and confers resistance to cell death

31 March 2020

1 reference

Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.

31 March 2020

1 reference

Models, mechanisms and clinical evidence for cancer dormancy

31 March 2020

1 reference

Dissemination and growth of cancer cells in metastatic sites

31 March 2020

1 reference

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

31 March 2020

1 reference

Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

31 March 2020

1 reference

Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression

31 March 2020

1 reference

Cancer theory faces doubts

31 March 2020

1 reference

Epithelial-mesenchymal transition and cell cooperativity in metastasis

31 March 2020

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Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

31 March 2020

1 reference

Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

31 March 2020

1 reference

The basics of epithelial-mesenchymal transition

31 March 2020

1 reference

Prognostic value of tumor "budding" in patients with colorectal cancer

31 March 2020

1 reference

ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients

31 March 2020

1 reference

A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer

31 March 2020

1 reference

Tumour budding as prognostic factor in stage I/II colorectal carcinoma

31 March 2020

1 reference

Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer.

31 March 2020

1 reference

Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2.

31 March 2020

1 reference

Molecular definition of breast tumor heterogeneity

31 March 2020

1 reference

Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients

31 March 2020

1 reference

Detection, clinical relevance and specific biological properties of disseminating tumour cells

31 March 2020

1 reference

Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype

31 March 2020

1 reference

Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity

31 March 2020

1 reference

Isolation of rare circulating tumour cells in cancer patients by microchip technology

31 March 2020

1 reference

Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome

31 March 2020

1 reference

Interactions between cancer stem cells and their niche govern metastatic colonization

31 March 2020

1 reference

Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression

31 March 2020

1 reference

Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2.

31 March 2020

1 reference

Mesenchymal to epithelial transition in development and disease.

31 March 2020

1 reference

miR-200 enhances mouse breast cancer cell colonization to form distant metastases

31 March 2020

1 reference

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

31 March 2020

1 reference

Dunning rat prostate adenocarcinomas and alternative splicing reporters: powerful tools to study epithelial plasticity in prostate tumors in vivo

31 March 2020

1 reference

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity

31 March 2020

1 reference

EMT and dissemination precede pancreatic tumor formation

31 March 2020

1 reference

The metastatic niche: adapting the foreign soil

31 March 2020

1 reference

The epithelial cell default-phenotype hypothesis and its implications for cancer

31 March 2020

1 reference

E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression.

31 March 2020

1 reference

Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin

31 March 2020

1 reference

Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition.

31 March 2020

1 reference

Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney

31 March 2020

1 reference

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

31 March 2020

1 reference

BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo

31 March 2020

1 reference

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

31 March 2020

1 reference

Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids

31 March 2020

1 reference

Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition

31 March 2020

1 reference

Parallel progression of primary tumours and metastases

31 March 2020

1 reference

Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

31 March 2020

1 reference

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

31 March 2020

1 reference

Deconstructing the molecular portraits of breast cancer

31 March 2020

1 reference

Triple-Negative Breast Cancer: Clinical and Histological Correlations.

31 March 2020

1 reference

Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer.

31 March 2020

1 reference

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

31 March 2020

1 reference

Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition

31 March 2020

1 reference

Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

31 March 2020

1 reference

Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells

31 March 2020

1 reference

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

31 March 2020

1 reference

Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma

31 March 2020

1 reference

CD133+ anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin

31 March 2020

1 reference

Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas.

31 March 2020

1 reference

Hereditary diffuse gastric cancer: a manifestation of lost cell polarity

31 March 2020

1 reference

Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma.

31 March 2020

1 reference

Therapeutic implications of the cancer stem cell hypothesis.

31 March 2020

1 reference

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

31 March 2020

1 reference

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

31 March 2020

1 reference

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

31 March 2020

1 reference

Cancer stemness and metastasis: therapeutic consequences and perspectives

31 March 2020

1 reference

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

31 March 2020

1 reference

Zeb1 links epithelial-mesenchymal transition and cellular senescence

31 March 2020

1 reference

The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells

31 March 2020

1 reference

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

31 March 2020

1 reference

EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells

31 March 2020

1 reference

Targeting Wnt signaling: can we safely eradicate cancer stem cells?

31 March 2020

1 reference

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

31 March 2020

1 reference

The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

31 March 2020

1 reference

Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

31 March 2020

1 reference

Mammary stem cells and breast cancer--role of Notch signalling.

31 March 2020

1 reference

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

31 March 2020

1 reference

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

31 March 2020

1 reference

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types

31 March 2020

1 reference

Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro

31 March 2020

1 reference

Identification of selective inhibitors of cancer stem cells by high-throughput screening

31 March 2020

1 reference

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

31 March 2020

1 reference

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

31 March 2020

1 reference

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

31 March 2020

1 reference

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

31 March 2020

1 reference

Metastasis: from dissemination to organ-specific colonization

31 March 2020

1 reference

Circulating tumor cells in patients with breast cancer dormancy

31 March 2020

1 reference

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas

31 March 2020

1 reference

12 December 2020

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget

1 reference

12 December 2020

Evaluation of the usefulness of tumor budding on the prediction of metastasis to the lung and liver after curative excision of colorectal cancer

1 reference

12 December 2020

Tumor budding at the invasive margin can predict patients at high risk of recurrence after curative surgery for stage II, T3 colon cancer

1 reference

12 December 2020

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

1 reference

12 December 2020

E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells

1 reference

12 December 2020

The zinc-finger transcription factor Snail downregulates proliferating cell nuclear antigen expression in colorectal carcinoma cells.

1 reference

12 December 2020

Metastatic Inefficiency

1 reference

12 December 2020