(Q84198989)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21614454%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits (English)

1 reference

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2 February 2020

author name string

Pancras C Wong

1

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2 February 2020

Earl J Crain

2

1 reference

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2 February 2020

Carol A Watson

3

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2 February 2020

William A Schumacher

4

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2 February 2020

publication date

1 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21614454%20AND%20SRC:MED&resulttype=core&format=json

Journal of Thrombosis and Thrombolysis

2 February 2020

published in

1 reference

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2 February 2020

volume

32

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2 February 2020

issue

2

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2 February 2020

page(s)

129-137

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https://scigraph.springernature.com/pub.10.1007/s11239-011-0599-0

2 February 2020

exact match

0 references

cites work

Factor XI deficiency in animal models

1 reference

12 December 2020

Plasma recalcification as a measure of contact phase activation and heparinization efficacy after contact with biomaterials

1 reference

12 December 2020

Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa

1 reference

12 December 2020

Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits.

1 reference

12 December 2020

Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery.

1 reference

12 December 2020

Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis

1 reference

12 December 2020

The intrinsic pathway of coagulation: a target for treating thromboembolic disease?

1 reference

12 December 2020

A comparative study of prothrombinase and thrombin inhibitors in a novel rabbit model of non-occlusive deep vein thrombosis

1 reference

12 December 2020

Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa

1 reference

12 December 2020

Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time

1 reference

12 December 2020

Management of catheter-induced venous thrombosis

1 reference

12 December 2020

Dual role of collagen in factor XII-dependent thrombus formation

1 reference

12 December 2020

New oral anticoagulants in development.

1 reference

12 December 2020

Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants

1 reference

12 December 2020

Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice

1 reference

12 December 2020

Effect of clot-detection methods and reagents on activated partial thromboplastin time (APTT). Implications in heparin monitoring by APTT.

1 reference

12 December 2020

Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents.

1 reference

12 December 2020

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.

1 reference

12 December 2020

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

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Factor XI deficiency in humans

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12 December 2020

Polyphosphate modulates blood coagulation and fibrinolysis.

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12 December 2020

Factor XI-dependence of surface- and tissue factor-initiated thrombus propagation in primates

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12 December 2020

Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis

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12 December 2020

Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice

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12 December 2020

Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats

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12 December 2020

New oral anticoagulant drugs in cardiovascular disease.

1 reference

12 December 2020

Inhibition of factor XIa as a new approach to anticoagulation

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12 December 2020

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

1 reference

12 December 2020

The Digestive Enzymes of the Pancreas: A Mixture of Inconstant Proportions

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12 December 2020

Blood coagulation on biomaterials requires the combination of distinct activation processes

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12 December 2020

FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse

1 reference

12 December 2020

Dabigatran for stroke prevention in atrial fibrillation: the RE-LY trial

1 reference

12 December 2020

Biology of mast cell tryptase. An inflammatory mediator

1 reference

12 December 2020

Dabigatran versus warfarin in patients with atrial fibrillation

1 reference

12 December 2020

Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis

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12 December 2020

Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

1 reference

12 December 2020

Quantifying biological activity in chemical terms: a pharmacology primer to describe drug effect

1 reference

12 December 2020

Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability

1 reference

12 December 2020

Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

1 reference

12 December 2020

Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function

1 reference

12 December 2020

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

1 reference

12 December 2020

The characterisation of thrombus development in an improved model of arterio-venous shunt thrombosis in the rat and the effects of recombinant desulphatohirudin (CGP 39393), heparin, and iloprost

1 reference

12 December 2020

Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model.

1 reference

12 December 2020

Nonpeptide factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics

1 reference

12 December 2020

10.1007/S11239-011-0599-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21614454%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference