(Q84417668)

English

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

scientific article published on 22 June 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

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inferred from title

1

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5 February 2020

author name string

G Jiang

2

1 reference

Europe PubMed Central

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5 February 2020

E Brady

3

1 reference

Europe PubMed Central

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5 February 2020

Q Dallas-Yang

4

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Europe PubMed Central

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5 February 2020

F Liu

5

1 reference

Europe PubMed Central

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5 February 2020

J Woods

6

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Europe PubMed Central

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5 February 2020

E Zycband

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

M Wright

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Z Li

9

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

K Lu

10

1 reference

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5 February 2020

L Zhu

11

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Europe PubMed Central

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5 February 2020

X Shen

12

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

R Sinharoy

13

1 reference

Europe PubMed Central

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5 February 2020

M L Candelore

14

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

S A Qureshi

15

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5 February 2020

D-M Shen

16

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Europe PubMed Central

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5 February 2020

F Zhang

17

1 reference

Europe PubMed Central

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5 February 2020

E R Parmee

18

1 reference

Europe PubMed Central

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5 February 2020

B B Zhang

19

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5 February 2020

publication date

22 June 2011

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5 February 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21695571%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

54

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5 February 2020

9

1 reference

Europe PubMed Central

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5 February 2020

2381-2391

1 reference

Europe PubMed Central

PubMed publication ID

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5 February 2020

https://scigraph.springernature.com/pub.10.1007/s00125-011-2217-2

0 references

Glycemic control in mice with targeted disruption of the glucagon receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human glucagon receptor antagonists based on alkylidene hydrazides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of liver in pathophysiology of NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon physiology and pathophysiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin therapy in insulin-deficient type I diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of mice expressing the human glucagon receptor with a direct replacement vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon: the effects of its excess and deficiency on insulin action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New approaches in the treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoregulation of endogenous glucose production during hyperglucagonemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of glucagon in maintenance of euglycemia in fed and fasted rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon and regulation of glucose metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New beta-alanine derivatives are orally available glucagon receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of alkylidene hydrazides as glucagon receptor antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a Major Role for Glucagon in Regulation of Plasma Glucose in Conscious, Nondiabetic, and Alloxan-Induced Diabetic Rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus. Pathophysiologic and therapeutic implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21695571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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