(Q84695824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-Solutions? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing—Solutions? (English)

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

18 June 2024

author name string

P. Skett

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20692944

18 June 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20692944

18 June 2024

publication date

1 June 1994

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

9 February 2020

https://api.elsevier.com/content/article/PII:0887233394901740?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

https://api.elsevier.com/content/article/PII:0887233394901740?httpAccept=text/plain

18 June 2024

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

18 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

491-504

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

Monolayer culture of parenchymal rat hepatocytes on collagen-coated microcarriers. A hepatocyte system for short- and long-term metabolic studies

9 February 2020

cites work

2

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase

18 June 2024

3

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Effect of phorbol esters and diacylglycerol on steroid metabolism in isolated rat hepatocytes

18 June 2024

4

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Influence of the isolation method on the stability of differentiated phenotype in cultured rat hepatocytes

18 June 2024

7

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The role of cyclic-AMP in the regulation of steroid metabolism in isolated rat hepatocytes

18 June 2024

8

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study

18 June 2024

9

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Parenchymal cells from adult rat liver in nonproliferating monolayer culture. I. Functional studies

18 June 2024

11

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes.

18 June 2024

13

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes

18 June 2024

14

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance of cytochrome P-450 and metabolism of aflatoxin B1 in primary hepatocyte cultures

18 June 2024

15

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Effects of a hormone-supplemented medium on cytochrome P-450 content and mono-oxygenase activities of rat hepatocytes in primary culture

18 June 2024

16

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Prolonged expression of biotransformation activities of rat hepatocytes co-cultured with established cell lines

18 June 2024

17

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes

18 June 2024

18

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Metal induction of haem oxygenase without concurrent degradation of cytochrome P-450. Protective effects of compound SKF 525A on the haem protein

18 June 2024

19

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Regulation of heme metabolism and cytochrome P-450 levels in primary culture of rat hepatocytes in a defined medium

18 June 2024

21

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Studies on the maintenance of cytochromes P-450 and b5, monooxygenases and cytochrome reductases in primary cultures of rat hepatocytes

18 June 2024

23

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Strain differences in the maintenance of cytochrome P-450 and mixed-function-oxidase activities in cultured rat hepatocytes. Effect of prostaglandins

18 June 2024

24

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type

18 June 2024

25

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance of cytochrome P-450 in cultured adult human hepatocytes.

18 June 2024

26

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Long term production of acute-phase proteins by adult rat hepatocytes co-cultured with another liver cell type in serum-free medium

18 June 2024

27

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Long-term culture of functional hepatocytes.

18 June 2024

28

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Interactions of insulin, thyroxine and dexamethasone with growth hormone in the control of steroid metabolism by isolated rat hepatocytes

18 June 2024

29

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Metabolism of drugs in isolated rat hepatocytes

18 June 2024

30

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The role of 5-aminolaevulinate synthase, haem oxygenase and ligand formation in the mechanism of maintenance of cytochrome P-450 concentration in hepatocyte culture

18 June 2024

31

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Regulation of cytochrome P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes

18 June 2024

32

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Hormonal regulations of alkaline phosphatase, 5'-nucleotidase and gamma-glutamyltransferase activities in adult rat hepatocytes cultured in serum-free medium on collagen gel

18 June 2024

33

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The enzymatic preparation of isolated intact parenchymal cells from rat liver

18 June 2024

34

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture

18 June 2024

35

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The effect of insulin on steroid metabolism in isolated rat hepatocytes

18 June 2024

36

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Isolated rat hepatocytes as a model to study drug metabolism: Dose-dependent metabolism of diphenylhydantoin

18 June 2024

37

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

A rapid method for the isolation of large quantities of rat liver parenchymal cells with high anabolic rates

18 June 2024

38

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance of differentiated rat hepatocytes in primary culture

18 June 2024

39

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Attachment and long term survival of adult rat hepatocytes in primary monolayer cultures: comparison of different substrata and tissue culture media formulations

18 June 2024

40

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes

18 June 2024

41

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Sulfation and glucuronidation of acetaminophen by cultured hepatocytes reproducing in vivo sex-differences in conjugation on Matrigel and type 1 collagen

18 June 2024

42

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance of liver-specific function in cultured hepatocytes in different media

18 June 2024

43

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The importance of proline on long-term hepatocyte function in a collagen gel sandwich configuration: regulation of protein secretion

18 June 2024

47

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone.

18 June 2024

48

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

High albumin production by multicellular spheroids of adult rat hepatocytes formed in the pores of polyurethane foam

18 June 2024

50

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Rat hepatocytes prepared without collagenase: prolonged retention of differentiated characteristics in culture

18 June 2024

51

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations

18 June 2024

52

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Amino acid-rich medium (Leibovitz L-15) enhances and prolongs proliferation of primary cultured rat hepatocytes in the absence of serum.

18 June 2024

53

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The bicarbonate ion is essential for efficient DNA synthesis by primary cultured rat hepatocytes

18 June 2024

54

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Extending effects of phospholipids, cholesterol, and ethanolamines on survival of adult rat hepatocytes in serum-free primary culture

18 June 2024

55

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture

18 June 2024

56

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Switching from differentiation to growth in hepatocytes: control by extracellular matrix

18 June 2024

57

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Regulation of glutathione S-transferase subunits 3 and 4 in cultured rat hepatocytes

18 June 2024

58

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Proline is required for transcriptional control of the aromatic hydrocarbon-inducible P(1)450 gene in C57BL/6 mouse monolayer-cultured hepatocytes

18 June 2024

59

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Differences in regulation of gene expression between Cyp1a-1 and Cyp1a-2 in adult mouse hepatocytes in primary culture

18 June 2024

60

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Rat adult hepatocytes in primary pure and mixed monolayer culture. Comparison of the maintenance of mixed function oxidase and conjugation pathways of drug metabolism

18 June 2024

61

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Altered expression of cytochrome P-450 mRNAs, and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes

18 June 2024

63

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance of total cytochrome P-450 content in rat hepatocyte culture and the abundance of CYP1A2 and CYP2B1/2 mRNAs

18 June 2024

64

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system

18 June 2024

65

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Ligands maintain cytochrome P-450 in liver cell culture by affecting its synthesis and degradation.

18 June 2024

66

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Evidence that ligand formation is a mechanism underlying the maintenance of cytochrome P-450 in rat liver cell culture. Potent maintenance by metyrapone

18 June 2024

67

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Apparent maintenance of cytochrome P 450 by nicotinamide in primary cultures of rat hepatocytes

18 June 2024

68

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes

18 June 2024

69

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Maintenance of bile acid synthesis and cholesterol 7 alpha-hydroxylase activity in cultured rat hepatocytes

18 June 2024

70

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes

18 June 2024

71

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes

18 June 2024

72

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Crude liver membrane fractions and extracellular matrix components as substrata regulate differentially the preservation and inducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes.

18 June 2024

73

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Induction of -aminolevulinic acid synthetase in chick embryo liver cells in cluture

18 June 2024

74

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

18 June 2024

75

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion

18 June 2024

76

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion

18 June 2024

77

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Stimulation of DNA synthesis and protooncogene expression in primary rat hepatocytes in long-term DMSO culture

18 June 2024

78

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

c-myc expression is down-regulated by cell-cell and cell-extracellular matrix contacts in normal hepatocytes, but not in hepatoma cells

18 June 2024

79

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Inhibition of glucuronidation and sulfation by dibutyryl cyclic AMP in isolated rat hepatocytes

18 June 2024

80

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix

18 June 2024

81

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

A mechanism for the loss of cytochrome P-450 in primary mouse hepatocytes

18 June 2024

82

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Biochemical basis of sex differences in drug metabolism

18 June 2024

84

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes

18 June 2024

86

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Effect of interleukin 1 (IL-1) on the levels of cytochrome P-450 involving IL-1 receptor on the isolated hepatocytes of rat.

18 June 2024

87

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Factors regulating drug metabolism in intact hepatocytes

18 June 2024

88

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Long-term culture of adult rat hepatocyte spheroids.

18 June 2024

89

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells

18 June 2024

90

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Dependency of the in vitro stabilization of differentiated functions in liver parenchymal cells on the type of cell line used for co-culture

18 June 2024

91

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Phenol sulfotransferase activity in rat liver parenchymal cells cultured on collagen gels

18 June 2024

92

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Transcriptional- and post-transcriptional-dependent regulation of glutathione S-transferase expression in rat hepatocytes as a function of culture conditions.

18 June 2024

93

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The effect of dexamethasone, insulin and triiodothyronine on microsomal NADPH-cytochrome-c (P-450) reductase in primary cultures of isolated hepatocytes

18 June 2024

94

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The content and activity of cytochrome P-450 in long-term culture of hepatocytes from male and female rats

18 June 2024

96

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Regulation by growth hormone and glucocorticoid of testosterone metabolism in long-term cultures of hepatocytes from male and female rats

18 June 2024

97

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Microcarrier-attached rat hepatocytes as a xenobiotic-metabolizing system in cocultures

18 June 2024

98

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Critical evaluation of methods used for the isolation of rat liver hepatocytes for metabolic studies

18 June 2024

99

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes

18 June 2024

100

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers

18 June 2024

101

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

Rapid decrease of cytochrome P-450IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole

18 June 2024

102

1 reference

https://api.crossref.org/works/10.1016/0887-2333(94)90174-0

18 June 2024

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20692944%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference