(Q84929019)

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Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: current recommendations from the Safety Pharmacology Society

scientific article published on 31 August 2011

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12 February 2020

Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: current recommendations from the Safety Pharmacology Society (English)

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12 February 2020

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D J Leishman

1

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12 February 2020

T W Beck

2

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12 February 2020

N Dybdal

3

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12 February 2020

D J Gallacher

4

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12 February 2020

B D Guth

5

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12 February 2020

M Holbrook

6

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12 February 2020

B Roche

7

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12 February 2020

R M Wallis

8

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12 February 2020

publication date

31 August 2011

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12 February 2020

Journal of Pharmacological and Toxicological Methods

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12 February 2020

65

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12 February 2020

3

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12 February 2020

93-101

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12 February 2020

Electrocardiographic findings in 67,375 asymptomatic subjects. I. Incidence of abnormalities

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Incidence and prognostic significance of ventricular arrhythmias in individuals without detectable heart disease

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Premature beats in healthy subjects 40-79 years of age

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Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease

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ILSI-HESI cardiovascular safety subcommittee dataset: an analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc).

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A one-step approach to the analysis of the QT interval in conscious telemetrized dogs.

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Statistical power analysis for hemodynamic cardiovascular safety pharmacology studies in beagle dogs.

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ECG arrhythmias in non-implanted vs. telemetry-implanted dogs: need for screening before and sufficient recovery time after implantation.

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Electrocardiogram, hemodynamics, and core body temperatures of the normal freely moving cynomolgus monkey by remote radiotelemetry

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7 January 2021

Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

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7 January 2021

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

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7 January 2021

Analysis of the nonclinical telemetered ECG: impact of logging rate and RR bin width in the dog and cynomolgus monkey

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7 January 2021

Novel probabilistic method for precisely correcting the QT interval for heart rate in telemetered dogs and cynomolgus monkeys

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7 January 2021

A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data

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7 January 2021

Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide

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7 January 2021

Optimizing the experimental environment for dog telemetry studies.

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7 January 2021

Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate

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7 January 2021

Cardiotoxicity associated with targeting kinase pathways in cancer

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7 January 2021

Effect of torcetrapib on the progression of coronary atherosclerosis

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A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.

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7 January 2021

Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs

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7 January 2021

Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs

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Cardiovascular function in nonclinical drug safety assessment: current issues and opportunities

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QT PRODACT: inter-facility variability in electrocardiographic and hemodynamic parameters in conscious dogs and monkeys

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Cardiovascular Risk-Benefit Profile of Sibutramine

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Prolongation of the QT interval by enflurane, isoflurane, and halothane in humans.

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7 January 2021

Cardiovascular safety assessments in the conscious telemetered dog: utilisation of super-intervals to enhance statistical power

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Different species require different correction factors for the QT interval.

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The future of drug safety testing: expanding the view and narrowing the focus

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Use of 24 h ambulatory ECG recordings in the assessment of new chemical entities in healthy volunteers

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Correction of QT values to allow for increases in heart rate in conscious Beagle dogs in toxicology assessment

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QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals

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The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: a versatile in vivo model in cardiovascular safety research

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10.1016/J.VASCN.2011.08.006

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12 February 2020

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21907296%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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