(Q85118779)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

author name string

Haiping Wang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Qi Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Yujun Shen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Aimin Sun

4

1 reference

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14 February 2020

Xiaoguang Zhu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Shengyun Fang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Yuxian Shen

7

1 reference

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14 February 2020

publication date

1 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20886262%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biochemistry

14 February 2020

published in

1 reference

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14 February 2020

volume

346

1 reference

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14 February 2020

issue

1-2

1 reference

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14 February 2020

page(s)

137-145

1 reference

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https://scigraph.springernature.com/pub.10.1007/s11010-010-0600-9

14 February 2020

exact match

0 references

cites work

The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes

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The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

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Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity

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Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response

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Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model.

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OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

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Alpha1-antitrypsin, old dog, new tricks. Alpha1-antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP

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Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

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Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

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Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

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12 December 2020

A frameshift mutation results in a truncated alpha 1-antitrypsin that is retained within the rough endoplasmic reticulum

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12 December 2020

Dimers initiate and propagate serine protease inhibitor polymerisation.

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12 December 2020

Role of ubiquitin in proteasomal degradation of mutant alpha(1)-antitrypsin Z in the endoplasmic reticulum

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12 December 2020

A thermostable mutation located at the hydrophobic core of alpha 1-antitrypsin suppresses the folding defect of the Z-type variant

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12 December 2020

Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys

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12 December 2020

ER stress and diseases.

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12 December 2020

Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum

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12 December 2020

Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk

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Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function

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Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants.

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12 December 2020

Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin

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12 December 2020