(Q85181125)

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Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells

scientific article published on 12 October 2010

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20938440%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20938440%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

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insulin resistance

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8

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15 February 2020

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S Famulla

1

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15 February 2020

D Lamers

2

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15 February 2020

S Hartwig

3

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15 February 2020

W Passlack

4

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15 February 2020

A Horrighs

5

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15 February 2020

A Cramer

6

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15 February 2020

S Lehr

7

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15 February 2020

J Eckel

9

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15 February 2020

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12 October 2010

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15 February 2020

International Journal of Obesity

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15 February 2020

35

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15 February 2020

6

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15 February 2020

762-772

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15 February 2020

Inflammation, stress, and diabetes

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Adipose tissue as an endocrine organ

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Endocrine and signalling role of adipose tissue: new perspectives on fat.

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PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity

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Pigment epithelium-derived factor contributes to insulin resistance in obesity.

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Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients

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Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome

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Characterization of PEDF: a multi-functional serpin family protein

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Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes

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Oleic acid and adipokines synergize in inducing proliferation and inflammatory signalling in human vascular smooth muscle cells

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Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture

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Autocrine action of adiponectin on human fat cells prevents the release of insulin resistance-inducing factors.

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From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes.

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Effect of sterol regulatory element binding protein-1a on the mitochondrial protein pattern in human liver cells detected by 2D-DIGE.

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Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

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Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration.

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice

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Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response

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Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor

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Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor

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Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation

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A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes.

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CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes

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Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes

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Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis

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Regulation of pigment epithelium-derived factor production and release by retinal glial (Müller) cells under hypoxia

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The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts

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Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia

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Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation.

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Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes

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Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes

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Effect of troglitazone on tumor necrosis factor alpha and transforming growth factor beta expression and action in human adipocyte precursor cells in primary culture

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Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells.

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Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma

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Pigment epithelium-derived factor (PEDF) inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties

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