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The new insights from DPP-4 inhibitors: their potential immune modulatory function in autoimmune diabetes
scientific article published on 01 November 2014
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Europe PubMed Central
PubMed publication ID
24446278
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
title
The new insights from DPP-4 inhibitors: their potential immune modulatory function in autoimmune diabetes
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
author
Yunjuan Zhao
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Zhiguang Zhou
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4
1 reference
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Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
author name string
Lin Yang
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2
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Europe PubMed Central
PubMed publication ID
24446278
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Xiangbing Wang
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3
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Europe PubMed Central
PubMed publication ID
24446278
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5 March 2020
publication date
1 November 2014
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
published in
Diabetes - Metabolism: Research and Reviews
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
volume
30
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
issue
8
1 reference
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Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
page(s)
646-653
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
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Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.
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Combined treatment with a dipeptidyl peptidase-IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells
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Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.
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Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor
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Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation
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Helper T cell diversity and plasticity
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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice
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Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?
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Immunology: T cells hang in the balance
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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
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Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children
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Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function
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The structure and function of CD26 in the T-cell immune response
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7 January 2021
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Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo
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Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients
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T-cell immune parameters and depression in patients with Crohn's disease.
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7 January 2021
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Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.
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DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis
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CD4(+) memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple sclerosis
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CD26/DPPIV signal transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2 cell lines as detected with living cell cytochemistry
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Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.
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7 January 2021
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Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice
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7 January 2021
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Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses
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Treatment of autoimmune diabetes in NOD mice by Toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition
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MECHANISMS OF CD26/DIPEPTIDYL PEPTIDASE IV CYTOKINE-DEPENDENT REGULATION ON HUMAN ACTIVATED LYMPHOCYTES
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Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen.
1 reference
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Enhanced ovalbumin-induced airway inflammation in CD26−/−mice
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7 January 2021
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Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions
1 reference
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7 January 2021
based on heuristic
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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
1 reference
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based on heuristic
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Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
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based on heuristic
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TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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based on heuristic
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TGF-beta signaling is required for the function of insulin-reactive T regulatory cells
1 reference
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7 January 2021
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Transforming growth factor-beta regulation of immune responses
1 reference
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7 January 2021
based on heuristic
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Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
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Reduced airway inflammation in CD26/DPP4-deficient F344 rats is associated with altered recruitment patterns of regulatory T cells and expression of pulmonary surfactant proteins
1 reference
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
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Crossref
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7 January 2021
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Th17: an effector CD4 T cell lineage with regulatory T cell ties
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
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T(H)-17 cells in the circle of immunity and autoimmunity
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
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CD26-mediated co-stimulation in human CD8(+) T cells provokes effector function via pro-inflammatory cytokine production
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
Altered proportions of naïve, central memory and terminally differentiated central memory subsets among CD4+ and CD8 + T cells expressing CD26 in patients with type 1 diabetes.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD26, let it cut or cut it down.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD26 is expressed on a restricted subpopulation of dendritic cells in vivo
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
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Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
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inferred from DOI database lookup
Dipeptidyl peptidase IV/CD26 in T cell activation, cytokine secretion and immunoglobulin production.
1 reference
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
1 reference
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reference URL
https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sitagliptin (MK0431) inhibition of dipeptidyl peptidase IV decreases nonobese diabetic mouse CD4+ T-cell migration through incretin-dependent and -independent pathways
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sitagliptin is effective and safe as add-on to insulin in patients with absolute insulin deficiency: a case series
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of sitagliptin on post-prandial glucagon and GLP-1 levels in patients with type 1 diabetes: investigator-initiated, double-blind, randomized, placebo-controlled trial
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (Dipeptidyl-peptidase IV; CD26) gene in rats
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FDMRR.2530
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7 January 2021
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DOI
10.1002/DMRR.2530
1 reference
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Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PubMed publication ID
24446278
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24446278
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446278%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
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