(Q87406656)

English

Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes

scientific article published on 07 March 2014

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scholarly article

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Europe PubMed Central

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9 March 2020

Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes (English)

1 reference

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9 March 2020

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type-1 diabetes

1 reference

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author name string

Anne Jörns

1

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9 March 2020

Muharrem Akin

2

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9 March 2020

Tanja Arndt

3

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9 March 2020

Taivankhuu Terbish

4

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9 March 2020

Andreas Meyer Zu Vilsendorf

5

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9 March 2020

Dirk Wedekind

6

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9 March 2020

Hans-Jürgen Hedrich

7

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9 March 2020

Sigurd Lenzen

8

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9 March 2020

publication date

7 March 2014

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9 March 2020

Journal of Molecular Medicine

1 reference

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9 March 2020

92

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9 March 2020

7

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9 March 2020

743-755

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9 March 2020

A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful prevention and treatment of autoimmune encephalomyelitis by short-term administration of anti-T-cell receptor alpha beta antibody.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-α/β T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic (NOD) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD3-specific antibodies restore self-tolerance: mechanisms and clinical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell subpopulations expressing distinct forms of the TCR in normal, athymic, and neonatally TCR alpha beta-suppressed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resetting the functional capacity of regulatory T cells: a novel immunotherapeutic strategy to promote immune tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics, pathogenesis and clinical interventions in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The level of circulating cytokines and chemokines in the preclinical and early clinical stages of type IA diabetes mellitus development

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy of type 1 diabetes--how to rationally prioritize combination therapies in T1D.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of CD3-specific antibodies in autoimmune diabetes: a step toward the induction of immune tolerance in the clinic

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-β dependent regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical immunosuppression in islet transplantation--friend or foe?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress towards the clinical use of CD3 monoclonal antibodies in the treatment of autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Etiology of type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of pancreatic beta-cell regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 1 diabetes: etiology, immunology, and therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-CD3 antibodies for type 1 diabetes: beyond expectations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased secretion of Th2 cytokines precedes Up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination therapies for type 1 diabetes: why not now?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell growth and regeneration: replication is only part of the story

1 reference

https://pubmed.ncbi.nlm.nih.gov/24599515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-014-1137-2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24599515%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24599515%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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