(Q87791958)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29445586%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Stressed Out - Therapeutic Implications of ER Stress Related Cancer Research (English)

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17 March 2020

1

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17 March 2020

Pooja Gupta-Saraf

2

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17 March 2020

author name string

Payel Bhanja

3

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17 March 2020

Samyak Badkul

4

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17 March 2020

Subhrajit Saha

5

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17 March 2020

publication date

27 September 2017

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17 March 2020

number of pages

12

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inferred from page(s)

volume

2

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17 March 2020

page(s)

156-167

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ASK1 is essential for JNK/SAPK activation by TRAF2

17 March 2020

cites work

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12 December 2020

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Induction of cell death by radiotherapy

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition.

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12 December 2020

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

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12 December 2020

Pancreatic tumors show high levels of hypoxia

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death

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12 December 2020

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

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12 December 2020

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

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12 December 2020

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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12 December 2020

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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12 December 2020

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

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12 December 2020

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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12 December 2020

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

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12 December 2020

Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells

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12 December 2020

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

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12 December 2020

The role of p53 in determining sensitivity to radiotherapy

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12 December 2020

A time-dependent phase shift in the mammalian unfolded protein response

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12 December 2020

Stress and radiation-induced activation of multiple intracellular signaling pathways

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12 December 2020

Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK

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12 December 2020

EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

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12 December 2020

Interferon‐γ induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis

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12 December 2020

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

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12 December 2020

Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements

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12 December 2020

Roles of CHOP/GADD153 in endoplasmic reticulum stress

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12 December 2020

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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12 December 2020

Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage

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12 December 2020

Activating transcription factor 4 is translationally regulated by hypoxic stress

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12 December 2020

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

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12 December 2020

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

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12 December 2020

Regulated folding of tyrosinase in the endoplasmic reticulum demonstrates that misfolded full-length proteins are efficient substrates for class I processing and presentation.

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12 December 2020

The impact of misfolding versus targeted degradation on the efficiency of the MHC class I-restricted antigen processing.

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12 December 2020

Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance

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12 December 2020

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

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12 December 2020

3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

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12 December 2020

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

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12 December 2020

Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis

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12 December 2020

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

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12 December 2020

IL-23 promotes tumour incidence and growth

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12 December 2020

A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma.

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12 December 2020

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

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12 December 2020

Hepatocellular carcinoma pathogenesis: from genes to environment

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12 December 2020

Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer

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12 December 2020

Calreticulin exposure dictates the immunogenicity of cancer cell death

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12 December 2020

Switch between apoptosis and autophagy: radiation-induced endoplasmic reticulum stress?

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12 December 2020

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

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12 December 2020

The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response

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12 December 2020

Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.

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12 December 2020

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

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12 December 2020

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

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12 December 2020

IL-6 involvement in epithelial cancers

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12 December 2020

6-Shogaol induces apoptosis in human colorectal carcinoma cellsviaROS production, caspase activation, and GADD 153 expression

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12 December 2020

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

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12 December 2020

Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study

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12 December 2020

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

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12 December 2020

Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways

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12 December 2020

Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib

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12 December 2020

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

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12 December 2020

ER stress affects processing of MHC class I-associated peptides

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12 December 2020

Cancer stem cells, hypoxia and metastasis

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12 December 2020

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib

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12 December 2020

Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells

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12 December 2020

Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat

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12 December 2020

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

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12 December 2020

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

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12 December 2020

Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells

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12 December 2020

Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24

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12 December 2020

Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients

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12 December 2020

ER stress induced by ionising radiation in IEC-6 cells

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12 December 2020

In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.

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12 December 2020

The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

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12 December 2020

Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications

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12 December 2020

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

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12 December 2020

Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.

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12 December 2020

Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma

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12 December 2020

Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling

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12 December 2020

Dominant expression of survival signals of endoplasmic reticulum stress response in Hodgkin lymphoma

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12 December 2020

Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial

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12 December 2020

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

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12 December 2020

A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling

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12 December 2020

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

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12 December 2020

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway

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12 December 2020

Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions

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12 December 2020

Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.

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12 December 2020

The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.

1 reference

12 December 2020

Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time

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12 December 2020

X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells

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12 December 2020

Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy

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12 December 2020

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

1 reference

12 December 2020

1 reference

12 December 2020

Induction of endoplasmic reticulum stress by sorafenib and activation of NF-κB by lestaurtinib as a novel resistance mechanism in Hodgkin lymphoma cell lines

1 reference

12 December 2020

Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8⁺ T cell priming

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12 December 2020

Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-κB activity in human oral cancer cells

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12 December 2020

Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress

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12 December 2020

Endoplasmic reticulum stress-induced resistance to doxorubicin is reversed by paeonol treatment in human hepatocellular carcinoma cells

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12 December 2020

Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin

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12 December 2020

Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer

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12 December 2020

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.

1 reference

12 December 2020

GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.

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12 December 2020

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.

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12 December 2020

Down-regulation of PERK enhances resistance to ionizing radiation

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12 December 2020

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.

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12 December 2020

Ionizing radiation activates PERK/eIF2α/ATF4 signaling via ER stress-independent pathway in human vascular endothelial cells.

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12 December 2020

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

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12 December 2020

Assessment of ER Stress and autophagy induced by ionizing radiation in both radiotherapy patients and ex vivo irradiated samples.

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12 December 2020

ER stress and autophagy dysfunction contribute to fatty liver in diabetic mice

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12 December 2020

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

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12 December 2020

World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma

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12 December 2020

Glutathione-S-transferase omega 1 (GSTO1-1) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis-autophagy crosstalk in macrophages

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12 December 2020

Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

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12 December 2020

Different Roles of CHOP and JNK in Mediating Radiation-Induced Autophagy and Apoptosis in Breast Cancer Cells.

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12 December 2020

Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer

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12 December 2020

Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.

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12 December 2020

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation

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12 December 2020

Identifiers

DOI

10.7150/ONCM.22477

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29445586%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29445586%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

29445586

1 reference