(Q88597093)

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MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

scientific article published on 24 July 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28741069%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28741069%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

mesenchymal stem cell

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based on heuristic

Seyed Javad Mowla

4

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Europe PubMed Central

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26 March 2020

7

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26 March 2020

8

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26 March 2020

author name string

Katayoon Pakravan

1

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26 March 2020

Sadegh Babashah

2

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26 March 2020

Majid Sadeghizadeh

3

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26 March 2020

Majid Mossahebi-Mohammadi

5

1 reference

Europe PubMed Central

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26 March 2020

Farangis Ataei

6

1 reference

Europe PubMed Central

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26 March 2020

publication date

24 July 2017

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Europe PubMed Central

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26 March 2020

Cellular Oncology

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26 March 2020

40

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26 March 2020

5

1 reference

Europe PubMed Central

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26 March 2020

457-470

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28741069%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Antiangiogenic cancer treatment: The great discovery and greater complexity (Review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR inhibitors, a new era for metastatic luminal HER2-negative breast cancer? A systematic review and a meta-analysis of randomized trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-99 family targets AKT/mTOR signaling pathway in dermal wound healing

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR inhibitors in the treatment of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of exosomes from cell culture supernatants and biological fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-100 suppresses mTOR signaling in hypoxia-induced pulmonary hypertension in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA and cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cell exosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of NF-kappaB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Veto-Like Activity of Mesenchymal Stem Cells: Functional Discrimination Between Cellular Responses to Alloantigens and Recall Antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of lymphangiogenesis and angiogenesis in tumor metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cells in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow-derived mesenchymal stem cells and the tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR signalling pathway in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretory mechanisms and intercellular transfer of microRNAs in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The therapeutic potential of mTOR inhibitors in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor angiogenesis: molecular pathways and therapeutic targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of miR-10b, miR-26a, miR-146a and miR-153 as potential triple-negative breast cancer biomarkers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concise review: mesenchymal stem cells and translational medicine: emerging issues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow-derived cells and tumor growth: contribution of bone marrow-derived cells to tumor micro-environments with special focus on mesenchymal stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast tumour angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/28741069

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S13402-017-0335-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28741069%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28741069%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

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