(Q90333269)

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NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies

scientific article published on 01 January 2019

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scholarly article

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12 April 2020

NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies (English)

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12 April 2020

author name string

Christian Schulz

1

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12 April 2020

Sarah Kammerer

2

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12 April 2020

Jan-Heiner Küpper

3

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12 April 2020

publication date

1 January 2019

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12 April 2020

Clinical Hemorheology and Microcirculation

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12 April 2020

73

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12 April 2020

249-260

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12 April 2020

1

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12 April 2020

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

13 November 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Cryopreservation of adult human hepatocytes. The influence of deep freezing storage on the viability, cell seeding, survival, fine structures and albumin synthesis in primary cultures.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

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Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

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Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

1 reference

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Activation of signalling pathways during hepatocyte isolation: relevance to toxicology in vitro

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Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

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Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

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Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures.

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

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The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.

1 reference

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HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

1 reference

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Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

1 reference

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Cytochrome p450 and chemical toxicology

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Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations

1 reference

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P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity

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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

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Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

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Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

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Consequences of POR mutations and polymorphisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

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Transcriptional regulation of the human P450 oxidoreductase gene: hormonal regulation and influence of promoter polymorphisms

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Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays

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https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

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Influence of various polymorphic variants of cytochrome P450 oxidoreductase (POR) on drug metabolic activity of CYP3A4 and CYP2B6

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Applications of CYP450 testing in the clinical setting

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of upcyte® human hepatocytes for the in vitro micronucleus assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell and tissue engineering for liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

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inferred from PubMed ID database lookup

Regulation of Liver Enriched Transcription Factors in Rat Hepatocytes Cultures on Collagen and EHS Sarcoma Matrices

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

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Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

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based on heuristic

inferred from PubMed ID database lookup

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https://pubmed.ncbi.nlm.nih.gov/31561354

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Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31561354

12 December 2020

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inferred from PubMed ID database lookup

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver

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https://pubmed.ncbi.nlm.nih.gov/31561354

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Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype

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https://pubmed.ncbi.nlm.nih.gov/31561354

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Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase

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1 reference

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Effect of P450 Oxidoreductase Polymorphisms on the Metabolic Activities of Ten Cytochrome P450s Varied by Polymorphic CYP Genotypes in Human Liver Microsomes

1 reference

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1 reference

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1 reference

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Identifiers

10.3233/CH-199226

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31561354%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31561354%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31561354%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

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