Wikidata

(Q906517)

English

CREB binding protein

mammalian protein found in Homo sapiens

  • RSTS
  • CREBBP
  • histone lysine acetyltransferase CREBBP
  • protein-lysine acetyltransferase CREBBP
  • CBP
  • KAT3A
  • Cyclic AMP Response Element-Binding Protein
  • CREB-binding protein
In more languages

Statements

part of
molecular function
transcription coactivator activity
determination method
IDA
IEA
TAS
IPI
10 references
retrieved
8 April 2019
stated in
CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
TAS
retrieved
8 April 2019
stated in
The sonic hedgehog-patched-gli pathway in human development and disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
TAS
retrieved
8 April 2019
stated in
Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
TAS
retrieved
8 April 2019
stated in
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IEA
retrieved
8 April 2019
stated in
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IDA
retrieved
8 April 2019
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IDA
retrieved
8 April 2019
stated in
P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IDA
retrieved
8 April 2019
stated in
The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IDA
protein binding
determination method
IPI
65 references
retrieved
8 April 2019
stated in
RNA helicase A mediates association of CBP with RNA polymerase II
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Dendrite development regulated by CREST, a calcium-regulated transcriptional activator
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles
GOA
curator
UniProt
UniProt protein ID
Q92793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
E1A directly binds and regulates the P/CAF acetyltransferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
The corepressor activity of Alien is controlled by CREB-binding protein/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of IRF-3 in complex with CBP.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Synergistic activation of transcription by CBP and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation-dependent signal transduction for type I interferon receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
cAMP-independent activation of the adenovirus type 12 E2 promoter correlates with the recruitment of CREB-1/ATF-1, E1A(12S), and CBP to the E2-CRE
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription.
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
retrieved
8 April 2019
stated in
MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92793
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE CREBBP 202160 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D050882
subject named as
CREB-Binding Protein
0 references
Freebase ID
/m/03bxv8s
0 references
PDB structure ID
 
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