(Q909381)

English

Interleukin 21

mammalian protein found in Homo sapiens

interleukin-21 isoform
IL21
interleukin-21
Za11

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9HBE4

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

interleukin-2 receptor binding

determination method

1 reference

8 April 2019

Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HBE4&geneProductId=UniProtKB:Q9HBE4

determination method

extracellular space

determination method

3 references

8 April 2019

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

biological process

positive regulation of inflammatory response

determination method

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of cytokine production

determination method

1 reference

8 April 2019

Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

cell maturation

determination method

1 reference

8 April 2019

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of B cell proliferation

determination method

1 reference

8 April 2019

Cloning and characterization of an isoform of interleukin-21

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of tissue remodeling

determination method

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

Cloning and characterization of an isoform of interleukin-21

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of interleukin-17 production

determination method

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of natural killer cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Interleukin-21 activates human natural killer cells and modulates their surface receptor expression

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

signal transduction

determination method

1 reference

8 April 2019

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

tyrosine phosphorylation of STAT protein

determination method

1 reference

8 April 2019

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

8 April 2019

Cloning and characterization of an isoform of interleukin-21

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

interleukin-21-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4

determination method

Gene Atlas image

PBB GE IL21 221271 at fs.png
732 × 530; 12 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

interleukin-21

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000477555

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477555

ENSP00000497915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497915

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(10 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q909381&oldid=2022902992"