(Q909646)

English

Heparanase

mammalian protein found in Homo sapiens

HPSE
heparanase
heparanase-1
Hpa1
endo-glucoronidase

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Glycoside hydrolase, family 79

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y251

glycoside hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y251

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein dimerization activity

determination method

1 reference

8 April 2019

Heterodimer formation is essential for heparanase enzymatic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

heparanase activity

determination method

beta-glucuronidase activity

determination method

1 reference

8 April 2019

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

hydrolase activity, acting on glycosyl bonds

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

protein binding

determination method

3 references

8 April 2019

Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

8 April 2019

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

8 April 2019

Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

syndecan binding

determination method

1 reference

8 April 2019

Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

heparanase activity

determination method

1 reference

8 April 2019

Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

determination method

2 references

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

lysosomal membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

lysosomal lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

determination method

specific granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

extracellular matrix

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

biological process

heparan sulfate proteoglycan catabolic process

determination method

1 reference

8 April 2019

Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

regulation of hair follicle development

determination method

1 reference

8 April 2019

Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

positive regulation of hair follicle development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

vascular wound healing

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

positive regulation of blood coagulation

determination method

1 reference

8 April 2019

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

proteoglycan metabolic process

determination method

1 reference

8 April 2019

Human heparanase. Purification, characterization, cloning, and expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

glycosaminoglycan catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

positive regulation of vascular endothelial growth factor production

determination method

1 reference

8 April 2019

Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

cell-matrix adhesion

determination method

1 reference

24 April 2018

Heparanase mediates cell adhesion independent of its enzymatic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y251&geneProductId=UniProtKB:Q9Y251

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251

determination method

Gene Atlas image

PBB GE HPSE 219403 s at fs.png
732 × 530; 11 KB

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000308107

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000308107

ENSP00000384262

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384262

ENSP00000421038

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421038

ENSP00000421365

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421365

ENSP00000423265

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423265

ENSP00000421827

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421827

ENSP00000426139

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426139

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(7 entries)

dewiki Heparanase
enwiki Heparanase
idwiki Heparanase
shwiki Heparanaza
srwiki Heparanaza
ttwiki HPSE
ukwiki HPSE

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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