(Q91996081)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

title

CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference

Streptomyces violaceus

1 reference

inferred from

reverse claim

Streptomyces olindensis

1 reference

1 reference

7-[4-(dimethylamino)-5-[4-hydroxy-5-(5-hydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-9-[4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-9-ethyl-1,6,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

1 reference

1 reference

1 reference

1 reference

(7S,9S)-7-[4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-9-ethyl-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione

1 reference

inferred from

reverse claim

9-[4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-7-[4-(dimethylamino)-5-[5-(5-hydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-9-ethyl-1,6,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

1 reference

1 reference

1 reference

OFMBTYXTQRCWOF-UHFFFAOYSA-N

1 reference

1 reference

methyl (1S,3R,4R)-1-[4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-3,10,12-trihydroxy-4-methyl-6,11-dioxo-2,4-dihydro-1H-tetracene-5-carboxylate

1 reference

inferred from

reverse claim

(9R)-9-ethyl-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Jianhua Ju

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

author name string

Chun Gui

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Jiang Chen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Qing Xie

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Xuhua Mo

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Shanwen Zhang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Hua Zhang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Qinglian Li

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Yu-Cheng Gu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

publication date

6 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

26 April 2020

https://www.nature.com/articles/s42003-019-0699-5.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1038/s42003-019-0699-5?email=unpaywall_01@example.com

published in

Communications Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

issue

1

1 reference

http://api.crossref.org/works/10.1038%2Fs42003-019-0699-5

page(s)

454

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1038/s42003-019-0699-5?email=unpaywall_01@example.com

access restriction status

open access

1 reference

based on heuristic

inferred from online access status

cites work

Self-resistance of natural product producers: Past, present and future focusing on self-resistant protein variants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic Pathway.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Anthracycline Chemotherapy and Cardiotoxicity.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Nivetetracyclates A and B: novel compounds isolated from Streptomyces niveus

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Bacterial inactivation of the anticancer drug doxorubicin.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

New anthracycline antibiotics produced by interspecific recombinants of streptomycetes. III. Isolation and structure of iremycin

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Anthracycline metabolites from Streptomyces violaceus A262. II. New anthracycline epelmycins produced by a blocked mutant strain SU2-730

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Anthracycline metabolites from Streptomyces violaceus A262. I. Isolation of antibiotic-blocked mutants from Streptomyces violaceus A262.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Structure-sensitivity relationship of anthracycline antibiotics to C7-reduction by redox enzymes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

The new cytotoxic antibiotic cytorhodin X, an unusual anthracyclinone-9 alpha-glycoside

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Reductive microbial conversion of anthracycline antibiotics

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

Mammalian and microbial cell-free conversion of anthracycline antibiotics and analogs

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6897945

The new cytotoxic antibiotic cytorhodin X, an unusual anthracyclinone-9.ALPHA.-glycoside.

23 February 2021

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS42003-019-0699-5

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S42003-019-0699-5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31840099%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

PubMed publication ID

31840099

1 reference