(Q94079090)

English

Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3

article by Pawel Kermer et al published 1 January 2000 in Journal of Neuroscience

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12 May 2020

Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3 (English)

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12 May 2020

retinal ganglion cell

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Pawel Kermer

1

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12 May 2020

Nikolaj Klöcker

2

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12 May 2020

Monika Labes

3

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12 May 2020

Mathias Bähr

4

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12 May 2020

publication date

1 January 2000

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12 May 2020

Journal of Neuroscience

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12 May 2020

20

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12 May 2020

2

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12 May 2020

722-728

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12 May 2020

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.

1 reference

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Long-term effect of inhibition of ced 3-like caspases on the survival of axotomized retinal ganglion cells in vivo

1 reference

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Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6772394

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1 reference

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1 reference

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Combined methods of retrograde staining, layer-separation and viscoelastic cell stabilization to isolate retinal ganglion cells in adult rats

1 reference

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1 reference

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Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats

1 reference

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Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo.

1 reference

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Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells

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11 February 2021

Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells In vivo.

1 reference

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11 February 2021

In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

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11 February 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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11 February 2021

Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury

1 reference

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Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat

1 reference

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Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases

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Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats.

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Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats.

1 reference

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11 February 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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11 February 2021

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells.

1 reference

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11 February 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

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11 February 2021

PI3K: downstream AKTion blocks apoptosis

1 reference

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

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Retinal ganglion cell axons recognize specific guidance cues present in the deafferented adult rat superior colliculus.

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Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit.

1 reference

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Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye

1 reference

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At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats

1 reference

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Flunarizine enhances rat retinal ganglion cell survival after axotomy

1 reference

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Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo.

1 reference

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Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival

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Insulin-like growth factor-I: potential for treatment of motor neuronal disorders

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Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells

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Apoptotic cell death induced by optic nerve lesion in the neonatal rat.

1 reference

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Apoptosis in adult retinal ganglion cells after axotomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6772394

11 February 2021

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.

1 reference

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Trophic factors and neuronal survival

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Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats

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Insulin-like growth factor-I expression is not increased in the retina of diabetic

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11 February 2021

Identifiers

10.1523/JNEUROSCI.20-02-00722.2000

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772394&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772394&resulttype=core&format=json

12 May 2020

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