Wikidata:WikiProject Chronic Pain/Fibromyalgia
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The role of Neuroinflammation (w, wd, src)
editNeuroinflamation is a potential cause and a proven underlying mechanism in Fibromyalgia.
- Inflammation (w, wd, src)
- Neuroimmune system (w, wd, src)
- Chemokine (w, wd, src)
- Interleukin (w, wd, src)
- Interleukin 6 (w, wd, src)
- Interleukin-1 (w, wd, src) a group of 11 w:cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
- Interleukin 1 beta (w, wd, src)
- Tumor necrosis factor alpha (w, wd, src) a cell signaling protein (w:cytokine) involved in systemic w:inflammation and is one of the cytokines that make up the w:acute phase reaction. It is produced chiefly by activated w:macrophages, although it can be produced by many other cell types such as w:CD4+ lymphocytes, w:NK cells, w:neutrophils, w:mast cells, w:eosinophils, and w:neurons.[1] The primary role of TNF is in the regulation of w:immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, w:cachexia, inflammation and to inhibit w:tumorigenesis and w:viral replication and respond to w:sepsis via IL1 & IL6 producing cells.
- Interleukin 10 (w, wd, src) an anti-inflammatory w:cytokine. In humans, interleukin 10 is encoded by the IL10 gene.[2] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins.[3] Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.[3]
- Myokine (w, wd, src) Foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation.[4] They also participate in tissue regeneration and repair, maintenance of healthy bodily functioning, immunomodulation; and cell signaling, expression and differentiation.[4]
Prevalence of traumatic events in the past
editWork in progress...
Other potential mechanisms
editArticles
edit- Mountly updated list of articles with main subject (P921) settled to fibromyalgia (Q540571), most recents first.
- Mountly updated list of articles with fibromyalgia (Q540571) in the title, most recents first.
- Dynamic list of articles with main subject (P921) settled to fibromyalgia (Q540571), most recents first.
- Dynamic list of articles with fibromyalgia (Q540571) in the title, most recents first.
References
edit- ↑ 9218250
- ↑ Eskdale J, Kube D, Tesch H, Gallagher G (1997). "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence". Immunogenetics. 46 (2): 120–8. doi:10.1007/s002510050250. PMID 9162098.
- ↑ 3.0 3.1 Mosser DM, Zhang X (December 2008). "Interleukin-10: new perspectives on an old cytokine". Immunological Reviews. 226 (1): 205–18. doi:10.1111/j.1600-065X.2008.00706.x. PMC 2724982. PMID 19161426.
- ↑ 4.0 4.1 Cite error: Invalid
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