Wikidata:WikiProject Chronic Pain/Fibromyalgia

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Title	Description
Wikidata Item	fibromyalgia Q540571
Wikidata description	chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness
Wikipedia articles	fibromyalgia (en) - fibromyalgie (fr) - Fibromyalgie (de) - fibromialgia (es) - fibromialgia (it) - 線維筋痛症 (ja) - fibromyalgia (cn) - 섬유근육통 (ko) - fibromyalgia (in) - ألم عضلي ليفي (ar)
symptoms and signs (P780)	chronic widespread pain, allodynia, fatigue, sleep disorder, mental depression and anxiety
has cause (P828)	unknown
afflicts (P689)	muscle, joints and central nervous system
risk factor (P5642)
medical examination (P923)	symptom and differential diagnosis
possible treatment (P924)	healthy diet, alternative medicine, sleep and psychotherapy
drug or therapy used for treatment (P2176)	anticonvulsant agent, non-steroidal anti-inflammatory drug, opioid, guaifenesin, serotonin–norepinephrine reuptake inhibitor, sodium oxybate, etanercept, amitriptyline, medical cannabis and alternative medicine
health specialty (P1995)
subclass of (P279)	myositis, chronic pain and disease
Links	Articles - Subtypes

The role of Neuroinflammation (w, wd, src)

Neuroinflamation is a potential cause and a proven underlying mechanism in Fibromyalgia.

• Inflammation (w, wd, src)
• Neuroimmune system (w, wd, src)

Neuroglia (w, wd, src)

• Microglia (w, wd, src)
• Astrocyte (w, wd, src)

Cytokine (w, wd, src)

• Chemokine (w, wd, src)
• Interleukin (w, wd, src)
  • Interleukin 6 (w, wd, src)
  • Interleukin-1 (w, wd, src) a group of 11 w:cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
    • Interleukin 1 beta (w, wd, src)
  • Tumor necrosis factor alpha (w, wd, src) a cell signaling protein (w:cytokine) involved in systemic w:inflammation and is one of the cytokines that make up the w:acute phase reaction. It is produced chiefly by activated w:macrophages, although it can be produced by many other cell types such as w:CD4+ lymphocytes, w:NK cells, w:neutrophils, w:mast cells, w:eosinophils, and w:neurons. The primary role of TNF is in the regulation of w:immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, w:cachexia, inflammation and to inhibit w:tumorigenesis and w:viral replication and respond to w:sepsis via IL1 & IL6 producing cells.
  • Interleukin 10 (w, wd, src) an anti-inflammatory w:cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.
• Myokine (w, wd, src) Foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation. They also participate in tissue regeneration and repair, maintenance of healthy bodily functioning, immunomodulation; and cell signaling, expression and differentiation.

Prevalence of traumatic events in the past

Work in progress...

Other potential mechanisms

• Fibromyalgia Caused By Malfunctions In Two Key Body Systems – Autonomic Nervous System and Hypothalamus-Pituitary-Adrenal Axis
• Work in progress...

Articles

• Mountly updated list of articles with main subject (P921) settled to fibromyalgia (Q540571), most recents first.
• Mountly updated list of articles with fibromyalgia (Q540571) in the title, most recents first.
• Dynamic list of articles with main subject (P921) settled to fibromyalgia (Q540571), most recents first.
• Dynamic list of articles with fibromyalgia (Q540571) in the title, most recents first.