(Q104667314)

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Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent

scientific article published on 27 October 2004

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Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent (English)

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Susan L. Mooberry

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Lizette Busquets

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2

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Georgia Tien

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3

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publication date

27 October 2004

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International Journal of Cancer

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volume

73

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issue

3

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page(s)

440-448

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cites work

Apoptosis. Its significance in cancer and cancer therapy

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Mechanism of action cryptophycin. Interaction with the Vinca alkaloid domain of tubulin.

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Drug-target interactions: only the first step in the commitment to a programmed cell death?

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Pharmaceuticals from cultured algae

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from the Blue-Green Alga Nostoc sp. Strain GSV 224

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Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells

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Structure determination, conformational analysis, chemical stability studies, and antitumor evaluation of the cryptophycins. Isolation of 18 new analogs from Nostoc sp. strain GSV 224

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Human ICE/CED-3 protease nomenclature

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Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

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Features of apoptotic cells measured by flow cytometry

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Interaction of cryptophycin 1 with tubulin and microtubules

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Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol

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Dynamic instability of microtubule growth

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Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

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Microtubule dynamics: taking aim at a moving target

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Premature p34cdc2 activation required for apoptosis.

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Cryptophycin 1 binds to tubulin at a site distinct from the colchicine binding site and at a site that may overlap the vinca binding site

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Apoptosis in cancer therapy: crossing the threshold

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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DOI

10.1002/(SICI)1097-0215(19971104)73:3<440::AID-IJC20>3.0.CO;2-F

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(Q104667314)

Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent

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