(Q105168602)

English

Oligomycin A

chemical compound

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No description defined

Statements

type of chemical entity

0 references

1 reference

based on heuristic

inferred from SMILES

(4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,27S,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione

1 reference

based on heuristic

inferred from SMILES

1 reference

based on heuristic

inferred from SMILES

1 reference

based on heuristic

inferred from SMILES

(1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione

1 reference

based on heuristic

inferred from SMILES

790.523113188 dalton

1 reference

based on heuristic

inferred from SMILES

stereoisomer of

2 references

based on heuristic

inferred from InChIKey

based on heuristic

inferred from InChI

2 references

based on heuristic

inferred from InChIKey

based on heuristic

inferred from InChI

(1R,4S,5'R,6'R,10S,11R,12S,14R,15S,16S,18R,19S,20R,25S,26R,27S,29S)-4-ethyl-11,12,15,19-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',10,12,14,16,18,20,26,29-nonamethylspiro[24,28-dioxabicyclo[23.3.1]nonacosa-5,7,21-triene-27,2'-oxane]-13,17,23-trione

1 reference

based on heuristic

inferred from InChI

chemical formula

C₄₅H₇₄O₁₁

0 references

canonical SMILES

O=C1OC2C(C)C(OC3(OC(CC(O)C)C(C)CC3)C2C)CCC(C=CC=CCC(C)C(O)C(O)(C(=O)C(C)C(O)C(C(=O)C(C)C(O)C(C=C1)C)C)C)CC

0 references

isomeric SMILES

CC[C@@H]1/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)/C=C/C(=O)O[C@H]2[C@@H](C)[C@@H](CC1)O[C@@]1(CC[C@@H](C)[C@@H](C[C@H](C)O)O1)[C@@H]2C

0 references

Streptomyces libani

14 references

Isolation, identification, and antifungal activity of a macrolide antibiotic, oligomycin A, produced by Streptomyces libani

Isolation, identification, and antifungal activity of a macrolide antibiotic, oligomycin A, produced by Streptomyces libani

Isolation, identification, and antifungal activity of a macrolide antibiotic, oligomycin A, produced by Streptomyces libani

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces diastatochromogenes

12 references

Structure determination of oligomycins A and C

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces avermitilis

13 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

The lack of antifungal activity by avermectin Bla.

Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

Streptomyces albidoflavus

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces coelicolor

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces diastaticus

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces fradiae

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces griseolus

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces hygroscopicus

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces xinghaiensis

11 references

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Streptomyces halstedii

11 references

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT-A37.

The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis.

Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

Oligomycins A and E, major bioactive secondary metabolites produced by Streptomyces sp. strain HG29 isolated from a Saharan soil.

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Draft Genome Sequence of Streptomyces xinghaiensis () OlgR, a Strain Resistant to Oligomycin A

Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro

3 references

Oligomycin F, a new immunosuppressive homologue of oligomycin A

Oligomycin E, a new antitumor antibiotic produced by Streptomyces sp. MCI-2225.

Biosynthetic origins of the large macrolide, oligomycin A

Identifiers

InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1

0 references

MNULEGDCPYONBU-WMBHJXFZSA-N

0 references

1 reference

matched by identifier from

MNULEGDCPYONBU-WMBHJXFZSA-N

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

MNULEGDCPYONBU-WMBHJXFZSA-N

UniChem compound ID

1 reference

Natural Product Atlas ID

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

MNULEGDCPYONBU-WMBHJXFZSA-N

Probes And Drugs ID

0 references

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