(Q14860215)

Hint domain superfamily

1 reference

hedgehog protein

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Hint domain N-terminal domain, protein family

1 reference

Hint domain C-terminal domain, protein family

1 reference

Hedgehog protein, Hint domain, protein family

1 reference

Hedgehog, N-terminal signalling domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

9 August 2016

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

5 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Characterization of two patched receptors for the vertebrate hedgehog protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

9 August 2016

A sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Megalin functions as an endocytic sonic hedgehog receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

All Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved Manner

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Characterization of two patched receptors for the vertebrate hedgehog protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

2 references

1 reference

8 April 2019

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

2 references

1 reference

16 September 2017

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62226&geneProductId=UniProtKB:Q62226

intracellular anatomical structure

1 reference

16 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62226&geneProductId=UniProtKB:Q62226

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Proteolytic processing yields two secreted forms of sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Proteolytic processing yields two secreted forms of sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

pattern specification process

biological process

positive regulation of immature T cell proliferation in thymus

oligodendrocyte differentiation

4 references

9 August 2016

14 February 2019

Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Specific requirements of sonic hedgehog signaling during oligodendrocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

prostate gland development

3 references

9 August 2016

8 April 2019

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

8 April 2019

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

8 April 2019

Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

embryonic digestive tract morphogenesis

TAS

inner ear development

3 references

9 August 2016

8 April 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

hair follicle morphogenesis

4 references

9 August 2016

8 April 2019

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Shh expression is required for embryonic hair follicle but not mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling is essential for hair development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

branching involved in salivary gland morphogenesis

3 references

9 August 2016

8 April 2019

Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

renal system development

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

regulation of transcription, DNA-templated

positive regulation of smoothened signaling pathway

3 references

5 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

7 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

negative regulation of cell differentiation

3 references

9 August 2016

8 April 2019

Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

embryonic digit morphogenesis

6 references

9 August 2016

8 April 2019

Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Gas1 extends the range of Hedgehog action by facilitating its signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

lymphoid progenitor cell differentiation

4 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Reduced thymocyte development in sonic hedgehog knockout embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of transcription, DNA-templated

5 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

A role for WNT proteins in induction of dermomyotome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

8 April 2019

Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog is required for cardiac outflow tract and neural crest cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

embryonic limb morphogenesis

4 references

9 August 2016

8 April 2019

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Regulation of pancreas development by hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Regulation of pancreas development by hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

smoothened signaling pathway

6 references

9 August 2016

14 February 2019

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

camera-type eye development

5 references

9 August 2016

8 April 2019

Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

3 references

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

cell fate specification

4 references

9 August 2016

14 February 2019

Specification of the mammalian cochlea is dependent on Sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

negative regulation of transcription by RNA polymerase II

3 references

9 August 2016

8 April 2019

Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

3 references

regulation of prostatic bud formation

regulation of gene expression

6 references

9 August 2016

14 February 2019

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

14 February 2019

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

dorsal/ventral neural tube patterning

5 references

9 August 2016

8 April 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

epithelial-mesenchymal signaling involved in prostate gland development

4 references

9 August 2016

8 April 2019

Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

branching morphogenesis of an epithelial tube

4 references

9 August 2016

8 April 2019

Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

embryonic forelimb morphogenesis

ventral spinal cord interneuron specification

2 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of hh target transcription factor activity

5 references

9 August 2016

8 April 2019

Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

3 references

9 August 2016

8 April 2019

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

8 April 2019

Sonic hedgehog is essential for first pharyngeal arch development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

hindbrain development

3 references

9 August 2016

8 April 2019

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

cerebellar granule cell precursor proliferation

3 references

9 August 2016

8 April 2019

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

4 references

9 August 2016

8 April 2019

Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Loss of Gli3 and Shh function disrupts olfactory axon trajectories

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

multicellular organism development

intein-mediated protein splicing

3 references

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

determination of left/right symmetry

4 references

9 August 2016

8 April 2019

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The SIL gene is required for mouse embryonic axial development and left-right specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of gene expression

3 references

9 August 2016

8 April 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

embryonic morphogenesis

positive regulation of cell population proliferation

10 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Shh controls epithelial proliferation via independent pathways that converge on N-Myc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Shh controls epithelial proliferation via independent pathways that converge on N-Myc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

3 references

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

4 references

9 August 2016

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

striated muscle cell differentiation

epithelial tube branching involved in lung morphogenesis

3 references

9 August 2016

8 April 2019

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of transcription by RNA polymerase II

14 references

9 August 2016

8 April 2019

Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of neuroblast proliferation

1 reference

9 August 2016

telencephalon regionalization

1 reference

9 August 2016

regulation of cell population proliferation

1 reference

9 August 2016

negative regulation of apoptotic process

1 reference

9 August 2016

neural tube formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

digestive tract mesoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

zona limitans intrathalamica formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of neurotrophin production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

negative regulation of apoptotic process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of photoreceptor cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

response to axon injury

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

male genitalia morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of penile erection

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

fungiform papilla development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

fungiform papilla morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

fungiform papilla formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of oligodendrocyte progenitor proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

commissural neuron axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

negative regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

tracheoesophageal septum formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

positive regulation of endothelial cell chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

Specification of the mammalian cochlea is dependent on Sonic hedgehog

cell fate specification

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

smoothened signaling pathway

6 references

8 April 2019

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

regulation of gene expression

6 references

8 April 2019

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

oligodendrocyte differentiation

4 references

8 April 2019

Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Specific requirements of sonic hedgehog signaling during oligodendrocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226

Zone of polarizing activity

expressed in

0 references

has part(s)

Intein N-terminal splicing region

1 reference

Hedgehog, N-terminal signalling domain

1 reference

Hint domain N-terminal

1 reference

Hint domain C-terminal

1 reference

Hedgehog protein, Hint domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016