(Q14903410)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

transforming growth factor beta receptor binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

6 references

14 February 2019

LRP2/megalin is required for patterning of the ventral telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

IPI

chemoattractant activity

3 references

growth factor activity

protein homodimerization activity

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

BMP4 substitutes for loss of BMP7 during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo

germ cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

embryonic skeletal system morphogenesis

1 reference

14 February 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

mesenchymal cell differentiation involved in renal system development

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

ureteric bud development

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of protein phosphorylation

3 references

1 reference

14 February 2019

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of endothelial cell differentiation

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of immature T cell proliferation in thymus

3 references

bud elongation involved in lung branching

1 reference

14 February 2019

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

tendon cell differentiation

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

anatomical structure formation involved in morphogenesis

1 reference

14 February 2019

Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

ureter epithelial cell differentiation

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of cell cycle

3 references

outflow tract morphogenesis

1 reference

14 February 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

mesenchymal to epithelial transition involved in metanephros morphogenesis

3 references

post-embryonic development

3 references

14 February 2019

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

3 references

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

3 references

BMP signaling pathway involved in renal system segmentation

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

cranial suture morphogenesis

1 reference

14 February 2019

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

mesonephros development

ISS

odontogenesis of dentin-containing tooth

2 references

3 references

14 February 2019

Regulation of mammalian tooth cusp patterning by ectodin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Regulation of mammalian tooth cusp patterning by ectodin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of chondrocyte differentiation

1 reference

14 February 2019

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

Genetic variability and rodent models of human aging

blood vessel development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of mitotic nuclear division

3 references

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

prostate gland morphogenesis

1 reference

14 February 2019

Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

smooth muscle tissue development

1 reference

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of endothelial cell proliferation

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

BMP signaling pathway involved in heart induction

TAS

3 references

negative regulation of epithelial cell proliferation

1 reference

14 February 2019

Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

metanephric collecting duct development

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

inner ear receptor cell differentiation

1 reference

14 February 2019

Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

mesodermal cell fate determination

1 reference

14 February 2019

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

metanephros development

type B pancreatic cell development

3 references

regulation of pathway-restricted SMAD protein phosphorylation

3 references

negative regulation of cell population proliferation

3 references

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

steroid hormone mediated signaling pathway

3 references

mammary gland formation

1 reference

14 February 2019

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of collagen biosynthetic process

3 references

1 reference

14 February 2019

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

common-partner SMAD protein phosphorylation

3 references

glomerular visceral epithelial cell development

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

SMAD protein signal transduction

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

BMP4 substitutes for loss of BMP7 during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

ureter smooth muscle cell differentiation

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

cardiac muscle cell differentiation

NAS

embryonic digit morphogenesis

1 reference

14 February 2019

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

epithelial-mesenchymal cell signaling

1 reference

14 February 2019

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of thymocyte apoptotic process

3 references

mesenchymal cell differentiation involved in kidney development

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of cell death

3 references

regulation of odontogenesis of dentin-containing tooth

1 reference

14 February 2019

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

BMP signaling pathway involved in ureter morphogenesis

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

mesenchymal cell proliferation involved in ureteric bud development

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

smooth muscle cell differentiation

1 reference

14 February 2019

Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

lymphoid progenitor cell differentiation

3 references

epithelium development

1 reference

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of transcription, DNA-templated

4 references

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

deltoid tuberosity development

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

branching involved in ureteric bud morphogenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

cartilage development

1 reference

14 February 2019

positive regulation of kidney development

3 references

negative regulation of MAP kinase activity

3 references

lens induction in camera-type eye

1 reference

14 February 2019

BMP4 is essential for lens induction in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of cell differentiation

1 reference

14 February 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

branching involved in prostate gland morphogenesis

1 reference

14 February 2019

Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

erythrocyte differentiation

1 reference

14 February 2019

BMP4 and Madh5 regulate the erythroid response to acute anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

smoothened signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

camera-type eye development

secondary heart field specification

3 references

negative regulation of phosphorylation

3 references

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

14 February 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of cell fate commitment

3 references

regulation of branching involved in prostate gland morphogenesis

1 reference

14 February 2019

Computer-based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo-insufficient for bone morphogenetic protein 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of branching involved in lung morphogenesis

1 reference

14 February 2019

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

chondrocyte differentiation

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of cartilage development

1 reference

14 February 2019

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

Formation of Rathke's pouch requires dual induction from the diencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of bone mineralization

3 references

positive regulation of epithelial cell proliferation

negative regulation of cell proliferation involved in heart morphogenesis

3 references

regulation of morphogenesis of a branching structure

1 reference

14 February 2019

Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of apoptotic process

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

positive regulation of ossification

3 references

14 February 2019

Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

endochondral ossification

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of smooth muscle cell proliferation

1 reference

14 February 2019

Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

BMP signaling pathway

6 references

24 April 2018

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

embryonic skeletal system development

1 reference

14 February 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of metanephric comma-shaped body morphogenesis

3 references

3 references

mesenchymal cell proliferation involved in ureter development

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of osteoblast differentiation

3 references

osteoblast differentiation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

hematopoietic progenitor cell differentiation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of BMP signaling pathway

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of gene expression

embryonic cranial skeleton morphogenesis

1 reference

14 February 2019

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

dorsal/ventral neural tube patterning

1 reference

14 February 2019

Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

anterior/posterior axis specification

1 reference

14 February 2019

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of transcription, DNA-templated

3 references

positive regulation of epidermal cell differentiation

3 references

branching morphogenesis of an epithelial tube

3 references

1 reference

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

specification of animal organ position

1 reference

14 February 2019

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of glomerular mesangial cell proliferation

3 references

positive regulation of smooth muscle cell proliferation

3 references

positive regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

intermediate mesodermal cell differentiation

TAS

3 references

pulmonary artery endothelial tube morphogenesis

3 references

pituitary gland development

1 reference

14 February 2019

Formation of Rathke's pouch requires dual induction from the diencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of endothelial cell proliferation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of cardiac muscle fiber development

3 references

positive regulation of cell migration

1 reference

14 February 2019

DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

3 references

cellular response to growth factor stimulus

1 reference

14 February 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of pathway-restricted SMAD protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

BMP signaling pathway involved in nephric duct formation

3 references

negative regulation of mesenchymal cell proliferation involved in ureter development

3 references

glomerular capillary formation

1 reference

14 February 2019

Bmp in podocytes is essential for normal glomerular capillary formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of endothelial cell migration

4 references

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of metanephric S-shaped body morphogenesis

3 references

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

vasculature development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

Distinct functions for Bmp signaling in lip and palate fusion in mice

embryonic morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

protein localization to nucleus

3 references

positive regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

mesodermal cell differentiation

1 reference

14 February 2019

Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of branching involved in ureteric bud morphogenesis

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

10 September 2018

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

1 reference

14 February 2019

Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

camera-type eye morphogenesis

1 reference

14 February 2019

Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of transcription by RNA polymerase II

16 references

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Molecular mechanisms of cell and tissue interactions during early tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of SMAD protein signal transduction

3 references

negative regulation of glomerulus development

3 references

embryonic hindlimb morphogenesis

1 reference

14 February 2019

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

outflow tract septum morphogenesis

membranous septum morphogenesis

pharyngeal arch artery morphogenesis

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

aortic valve morphogenesis

negative regulation of transcription by RNA polymerase II

4 references

24 April 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

24 April 2018

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

cardiac jelly development

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of cell proliferation involved in outflow tract morphogenesis

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

cardiac right ventricle morphogenesis

ISS

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

coronary vasculature development

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

BMP signaling pathway involved in heart development

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

pulmonary valve morphogenesis

negative regulation of extrinsic apoptotic signaling pathway

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

muscular septum morphogenesis

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

apoptotic process involved in endocardial cushion morphogenesis

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

endocardial cushion development

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

Bmp signaling represses Vegfa to promote outflow tract cushion development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

14 February 2019

Bmp signaling represses Vegfa to promote outflow tract cushion development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of gene expression

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

ovarian follicle development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of cell population proliferation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of calcium ion transport into cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of gene expression

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of neuron projection development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

cellular response to oxidative stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of oligodendrocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of hepatocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

cellular response to dexamethasone stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of store-operated calcium channel activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of mesenchymal stem cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

positive regulation of endothelial cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of transcription by RNA polymerase II

5 references

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

BMP signaling pathway

7 references

14 February 2019

14 February 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of apoptotic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of apoptotic process

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

regulation of MAPK cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

SMAD protein signal transduction

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

renal system development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

negative regulation of branching involved in ureteric bud morphogenesis

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

14 February 2019

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

Transforming growth factor beta, conserved site

has part(s)

1 reference

Transforming growth factor-beta, C-terminal

1 reference

TGF-beta, propeptide

1 reference