(Q14903951)

Dwarfin

1 reference

SMAD MH1 domain superfamily

1 reference

SMAD/FHA domain superfamily

1 reference

MAD homology, MH1, protein family

1 reference

based on heuristic

inferred from protein domain or family

SMAD domain, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

MAD homology 1, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

protein homodimerization activity

1 reference

14 February 2019

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

DNA-binding transcription factor activity

transcription factor binding

ISO

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

6 references

14 February 2019

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Identification of novel Smad binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

protein heterodimerization activity

IPI

1 reference

14 February 2019

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

double-stranded DNA binding

1 reference

14 February 2019

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

transcription regulator complex

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

intracellular anatomical structure

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62432&geneProductId=UniProtKB:Q62432

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

pattern specification process

TAS

biological process

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

paraxial mesoderm morphogenesis

1 reference

14 February 2019

Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Cell fate decisions within the mouse organizer are governed by graded Nodal signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

intracellular signal transduction

1 reference

14 February 2019

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

SMAD protein signal transduction

1 reference

14 February 2019

TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

Smad expression during kidney development

ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

embryonic pattern specification

IEP

1 reference

14 February 2019

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

embryonic foregut morphogenesis

1 reference

14 February 2019

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

in utero embryonic development

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

post-embryonic development

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

negative regulation of gene expression

1 reference

14 February 2019

Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62432&geneProductId=UniProtKB:Q62432

positive regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

positive regulation of transcription, DNA-templated

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

positive regulation of gene expression

1 reference

14 February 2019

Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

pericardium development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators

regulation of binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

embryonic cranial skeleton morphogenesis

1 reference

14 February 2019

Smad2 and Smad3 coordinately regulate craniofacial and endodermal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

transforming growth factor beta receptor signaling pathway

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

anterior/posterior pattern specification

3 references

14 February 2019

Cell fate decisions within the mouse organizer are governed by graded Nodal signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Nodal signalling in the epiblast patterns the early mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

positive regulation of transcription by RNA polymerase II

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

14 February 2019

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways

protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62432&geneProductId=UniProtKB:Q62432

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

adrenal gland development

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62432&geneProductId=UniProtKB:Q62432

secondary palate development

1 reference

14 February 2019

TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432

MAD homology 1, Dwarfin-type

has part(s)

1 reference

MAD homology, MH1

1 reference

SMAD domain, Dwarfin-type

1 reference