(Q35194715)

7 August 2017

title

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease (English)

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7 August 2017

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Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

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SMAD family member 2

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SMAD family member 2

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SMAD family member 3

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author name string

Uwe Ueberham

1

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7 August 2017

Susanne Rohn

2

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7 August 2017

Elke Ueberham

3

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7 August 2017

Susanne Wodischeck

4

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7 August 2017

Isabel Hilbrich

5

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7 August 2017

Max Holzer

6

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7 August 2017

Martina K Brückner

7

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7 August 2017

Hildegard Gruschka

8

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7 August 2017

Thomas Arendt

9

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7 August 2017

publication date

1 December 2014

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Neuropathology and Applied Neurobiology

7 August 2017

published in

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7 August 2017

volume

40

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7 August 2017

issue

7

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7 August 2017

page(s)

815-832

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Neuropathological stageing of Alzheimer-related changes

7 August 2017

cites work

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Examination of the validity of the hierarchical model of neuropathological staging in normal aging and Alzheimer's disease.

21 January 2018

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Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis.

21 January 2018

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Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease

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Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain

21 January 2018

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Altered subcellular location of phosphorylated Smads in Alzheimer's disease.

21 January 2018

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Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?

21 January 2018

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Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.

21 January 2018

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Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease

21 January 2018

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Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons.

21 January 2018

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Tau hyperphosphorylation affects Smad 2/3 translocation.

21 January 2018

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Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology

21 January 2018

1 reference

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

21 January 2018

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Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent

21 January 2018

1 reference

Pinning down cell signaling, cancer and Alzheimer's disease

21 January 2018

1 reference

Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease

21 January 2018

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Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in pre-mRNA 3'-End formation

21 January 2018

1 reference

Peptidyl-prolyl cis/trans isomerases and transcription: is there a twist in the tail?

21 January 2018

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Pin1: a therapeutic target in Alzheimer neurodegeneration

21 January 2018

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Molecular mechanisms of the phospho-dependent prolyl cis/trans isomerase Pin1.

21 January 2018

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Prolyl cis/trans isomerase signalling pathways in cancer

21 January 2018

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Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

21 January 2018

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Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism.

21 January 2018

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Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins

21 January 2018

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National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

21 January 2018

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Phases of A beta-deposition in the human brain and its relevance for the development of AD.

21 January 2018

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

21 January 2018

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

21 January 2018

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Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer.

21 January 2018

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Differentially expressed cortical genes contribute to perivascular deposition in transgenic mice with inducible neuron-specific expression of TGF-beta1.

21 January 2018

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RVG peptide as transfection reagent for specific cdk4 gene silencing in vitro and in vivo

21 January 2018

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Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects

21 January 2018

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Smad2 isoforms are differentially expressed during mouse brain development and aging

21 January 2018

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Characterization of a cytoskeletal matrix associated with myelin from rat brain

21 January 2018

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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

21 January 2018

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MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes

21 January 2018

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Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

21 January 2018

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Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias.

21 January 2018

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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

21 January 2018

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Phosphorylation-specific prolyl isomerization: is there an underlying theme?

21 January 2018

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Pin1 protein regulates Smad protein signaling and pulmonary fibrosis

21 January 2018

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Pin1 promotes transforming growth factor-beta-induced migration and invasion

21 January 2018

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A Smad action turnover switch operated by WW domain readers of a phosphoserine code

21 January 2018

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A human peptidyl-prolyl isomerase essential for regulation of mitosis

21 January 2018

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Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

21 January 2018

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Comparative analysis of enzyme activities and mRNA levels of peptidyl prolyl cis/trans isomerases in various organs of wild type and Pin1-/- mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/NAN.12163

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7 August 2017

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