Wikidata

(Q21116190)

English

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

mammalian protein found in Homo sapiens

  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
  • protein interacting with never in mitosis A1
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
  • PIN1
  • Peptidyl-prolyl cis-trans isomerase Pin1
  • PPIase Pin1
  • rotamase Pin1
  • NIMA-Interacting Peptidylprolyl Isomerase
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
27 references
retrieved
9 May 2019
stated in
Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1
GOA
curator
UniProt
UniProt protein ID
Q13526
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons
GOA
curator
UniProt
UniProt protein ID
Q13526
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Prolyl isomerase Pin1 enhances osteoblast differentiation through Runx2 regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Phosphorylation stabilizes Nanog by promoting its interaction with Pin1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IPI
peptidyl-prolyl cis-trans isomerase activity
determination method or standard
IBA
IDA
IEA
NAS
TAS
7 references
retrieved
1 January 2018
stated in
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
TAS
retrieved
1 January 2018
stated in
Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
TAS
retrieved
1 January 2018
stated in
Pin1 allows for differential Tau dephosphorylation in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
NAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13526
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
IEA
retrieved
1 January 2018
stated in
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13526&geneProductId=UniProtKB:Q13526
determination method or standard
IBA
peptidyl-prolyl cis-trans isomerase activity
determination method or standard
EXP
IBA
IDA
IEA
NAS
TAS
8 references
retrieved
9 May 2019
stated in
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
TAS
retrieved
9 May 2019
stated in
Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
TAS
retrieved
9 May 2019
stated in
Pin1 allows for differential Tau dephosphorylation in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
NAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13526
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IEA
retrieved
9 May 2019
stated in
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IBA
retrieved
9 May 2019
stated in
The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-α–induced priming of the NADPH oxidase in human neutrophils
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
EXP
cell component
nucleus
determination method or standard
IBA
IDA
IEA
TAS
8 references
retrieved
9 May 2019
stated in
A human peptidyl-prolyl isomerase essential for regulation of mitosis
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
TAS
retrieved
9 May 2019
stated in
Pin1 allows for differential Tau dephosphorylation in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13526
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IEA
retrieved
9 May 2019
stated in
Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
Q13526
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IDA
retrieved
9 May 2019
stated in
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IDA
retrieved
9 May 2019
stated in
Pin1 allows for differential Tau dephosphorylation in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13526
determination method or standard
IBA
biological process

Identifiers

MeSH descriptor ID
D000072340
subject named as
NIMA-Interacting Peptidylprolyl Isomerase
0 references
PDB structure ID