(Q14905570)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35235

Tumour necrosis factor ligand 10/11

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35235

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

tumor necrosis factor receptor superfamily binding

IPI

1 reference

9 May 2019

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

tumor necrosis factor receptor binding

IPI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

mammary gland epithelial cell proliferation

biological process

1 reference

9 May 2019

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

positive regulation of protein kinase B signaling

1 reference

9 May 2019

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of corticotropin-releasing hormone secretion

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

calcium ion homeostasis

1 reference

9 May 2019

Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

ossification

1 reference

9 May 2019

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

osteoclast differentiation

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

ERK1 and ERK2 cascade

1 reference

9 May 2019

Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

paracrine signaling

1 reference

9 May 2019

Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of osteoclast differentiation

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Leptin regulation of bone resorption by the sympathetic nervous system and CART

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of JNK cascade

1 reference

9 May 2019

LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

mammary gland alveolus development

1 reference

9 May 2019

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

bone resorption

1 reference

9 May 2019

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of osteoclast development

3 references

9 May 2019

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

regulation of osteoclast differentiation

positive regulation of fever generation by positive regulation of prostaglandin secretion

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

1 reference

9 May 2019

animal organ morphogenesis

1 reference

9 May 2019

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

TNFSF11-mediated signaling pathway

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

14 February 2019

NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of phosphorylation

1 reference

9 May 2019

Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

lymph node development

TAS

1 reference

9 May 2019

Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

protein homooligomerization

TAS

1 reference

9 May 2019

Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

osteoclast proliferation

1 reference

9 May 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

calcium-mediated signaling

1 reference

9 May 2019

Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

cellular response to leukemia inhibitory factor

IEP

1 reference

9 May 2019

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

regulation of signaling receptor activity

IEP

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

tooth eruption

1 reference

9 May 2019

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

bone development

1 reference

9 May 2019

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

osteoclast development

1 reference

9 May 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

regulation of actin binding

1 reference

9 May 2019

Regulation of vacuolar H(+)-ATPase in microglia by RANKL.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

osteoclast differentiation

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

positive regulation of osteoclast differentiation

IBA

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Leptin regulation of bone resorption by the sympathetic nervous system and CART

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

TNFSF11-mediated signaling pathway

IBA

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35235

Tumour necrosis factor domain

IBA

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35235

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016