(Q14905922)

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

Death-like domain superfamily

1 reference

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MyD88, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

18 references

9 May 2019

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Negative regulation of Toll-like-receptor signaling by IRF-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

identical protein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

Toll binding

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

signaling receptor binding

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

interleukin-1 receptor binding

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

protein self-association

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

Toll-like receptor binding

1 reference

8 April 2019

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

cell component

cytosol

1 reference

9 May 2019

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

plasma membrane

1 reference

8 April 2019

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

nucleus

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22366&geneProductId=UniProtKB:P22366

cytoplasm

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

postsynaptic density

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22366&geneProductId=UniProtKB:P22366

response to interleukin-1

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

establishment of endothelial intestinal barrier

1 reference

9 May 2019

Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of chemokine (C-X-C motif) ligand 1 production

1 reference

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of tumor necrosis factor production

1 reference

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

1 reference

9 May 2019

positive regulation of JNK cascade

1 reference

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of neutrophil migration

1 reference

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

cell surface receptor signaling pathway

1 reference

9 May 2019

Dectin-1 mediates the biological effects of beta-glucans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

response to lipopolysaccharide

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Dectin-1 mediates the biological effects of beta-glucans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

response to molecule of fungal origin

1 reference

9 May 2019

Dectin-1 mediates the biological effects of beta-glucans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

transmembrane receptor protein serine/threonine kinase signaling pathway

1 reference

9 May 2019

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of cell population proliferation

1 reference

9 May 2019

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

immunoglobulin mediated immune response

1 reference

9 May 2019

IRF-7 is the master regulator of type-I interferon-dependent immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

response to peptidoglycan

1 reference

9 May 2019

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

immune response

1 reference

9 May 2019

TIRAP: an adapter molecule in the Toll signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of inflammatory response

1 reference

9 May 2019

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

induced systemic resistance

1 reference

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Dectin-1 mediates the biological effects of beta-glucans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of gene expression

1 reference

9 May 2019

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

positive regulation of interleukin-17 production

1 reference

9 May 2019

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

1 reference

8 April 2019

3'-UTR-mediated mRNA stabilization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

positive regulation of lymphocyte proliferation

1 reference

9 May 2019

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

positive regulation of type I interferon production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

positive regulation of interleukin-23 production

1 reference

9 May 2019

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

lipopolysaccharide-mediated signaling pathway

1 reference

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

1 reference

9 May 2019

regulation of chemokine (C-X-C motif) ligand 2 production

1 reference

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

regulation of interleukin-6 production

1 reference

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

defense response to Gram-positive bacterium

MyD88-dependent toll-like receptor signaling pathway

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Dectin-1 mediates the biological effects of beta-glucans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

positive regulation of I-kappaB kinase/NF-kappaB signaling

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

cytokine-mediated signaling pathway

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

positive regulation of smooth muscle cell proliferation

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

Toll signaling pathway

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

positive regulation of NF-kappaB transcription factor activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

JNK cascade

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22366

type I interferon signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

positive regulation of interleukin-8 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

defense response to bacterium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

cellular response to oxidised low-density lipoprotein particle stimulus

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

phagocytosis

1 reference

8 April 2019

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

Toll signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

defense response to Gram-positive bacterium

IBA

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22366

1 reference

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

MyD88, death domain

1 reference