(Q14907191)

http://www.ebi.ac.uk/interpro/protein/P70380

Interleukin-18

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70380

1 reference

25 May 2022

1 reference

25 May 2022

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70380&geneProductId=UniProtKB:P70380

24 April 2018

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70380&geneProductId=UniProtKB:P70380

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70380&geneProductId=UniProtKB:P70380

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70380&geneProductId=UniProtKB:P70380

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70380&geneProductId=UniProtKB:P70380

24 April 2018

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70380&geneProductId=UniProtKB:P70380

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

interleukin-18 receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

apical plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

negative regulation of myoblast differentiation

biological process

1 reference

9 May 2019

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

natural killer cell activation

1 reference

9 May 2019

Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of gene expression

1 reference

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

inflammatory response

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

extrinsic apoptotic signaling pathway via death domain receptors

1 reference

9 May 2019

Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

TAS

triglyceride homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

cholesterol homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of macrophage derived foam cell differentiation

1 reference

9 May 2019

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of T-helper 2 cell differentiation

1 reference

9 May 2019

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

regulation of cell adhesion

3 references

9 May 2019

A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of interferon-gamma production

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

14 February 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

14 February 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

14 February 2019

Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

T-helper 1 type immune response

3 references

9 May 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of activated T cell proliferation

3 references

9 May 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

Accessory protein-like is essential for IL-18-mediated signaling

interleukin-6 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

interleukin-18-mediated signaling pathway

neutrophil activation

1 reference

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

natural killer cell mediated cytotoxicity

1 reference

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of NIK/NF-kappaB signaling

1 reference

9 May 2019

Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of smooth muscle cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of chemokine production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of interleukin-8 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of tumor necrosis factor production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of superoxide anion generation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of collagen biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

negative regulation of neutrophil apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of vascular permeability

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of neuron apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

negative regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

detection of mechanical stimulus involved in sensory perception of pain

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

cellular response to peptide hormone stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of male germ cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of blood vessel remodeling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of NF-kappaB transcription factor activity

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

positive regulation of T-helper 1 cell cytokine production

positive regulation of interferon-gamma production

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380

9 May 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70380