(Q14913839)

English

Sphingosine kinase 1

mammalian protein found in Mus musculus

sphingosine kinase 1
Sphk1
SPK 1
acetyltransferase SPHK1
SK 1
uniprot:Q8CI15

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CI15

NAD kinase/diacylglycerol kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CI15

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Diacylglycerol kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

D-erythro-sphingosine kinase activity

determination method

magnesium ion binding

determination method

NAD+ kinase activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

calmodulin binding

determination method

sphinganine kinase activity

determination method

D-erythro-sphingosine kinase activity

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Molecular cloning and functional characterization of murine sphingosine kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

sphinganine kinase activity

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

The nucleotide-binding site of human sphingosine kinase 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

acetyltransferase activity

determination method

1 reference

9 May 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

plasma membrane

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

synaptic vesicle

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

neuron projection

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

endocytic vesicle

determination method

1 reference

9 May 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

9 May 2019

Coupling between endocytosis and sphingosine kinase 1 recruitment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

clathrin-coated pit

determination method

endosome membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

early endosome membrane

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

biological process

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

sphingosine metabolic process

determination method

regulation of tumor necrosis factor-mediated signaling pathway

determination method

brain development

determination method

1 reference

9 May 2019

Essential role for sphingosine kinases in neural and vascular development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

blood vessel development

determination method

1 reference

9 May 2019

Essential role for sphingosine kinases in neural and vascular development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Essential role for sphingosine kinases in neural and vascular development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

regulation of interleukin-1 beta production

determination method

1 reference

9 May 2019

Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

inflammatory response

determination method

1 reference

9 May 2019

Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of protein ubiquitination

determination method

lipid phosphorylation

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

sphingosine-1-phosphate receptor signaling pathway

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CI15&geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of NIK/NF-kappaB signaling

determination method

positive regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of neurotransmitter secretion

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of neuron projection development

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

cyclooxygenase pathway

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of mitotic nuclear division

determination method

1 reference

9 May 2019

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

cellular response to hydrogen peroxide

determination method

1 reference

9 May 2019

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

DNA biosynthetic process

determination method

1 reference

9 May 2019

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

sphingolipid mediated signaling pathway

determination method

1 reference

9 May 2019

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

protein acetylation

determination method

1 reference

9 May 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

regulation of endocytosis

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

8 April 2019

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

8 April 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of interleukin-17 production

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

negative regulation of apoptotic process

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

regulation of phagocytosis

determination method

1 reference

9 May 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

regulation of microglial cell activation

determination method

1 reference

9 May 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

regulation of endosomal vesicle fusion

determination method

1 reference

9 May 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

regulation of endocytosis

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

response to tumor necrosis factor

determination method

cellular response to vascular endothelial growth factor stimulus

determination method

regulation of neuroinflammatory response

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

negative regulation of ceramide biosynthetic process

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CI15

determination method

positive regulation of p38MAPK cascade

determination method

Diacylglycerol kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CI15

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000064743

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000064743

ENSMUSP00000067865

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000067865

ENSMUSP00000097775

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000097775

ENSMUSP00000101994

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101994

ENSMUSP00000101995

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101995

ENSMUSP00000101996

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101996

ENSMUSP00000131010

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000131010

ENSMUSP00000114622

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000114622

ENSMUSP00000114819

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000114819

ENSMUSP00000116055

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000116055

ENSMUSP00000121064

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121064

ENSMUSP00000121219

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121219

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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