(Q14914104)

English

Toll-like receptor 4

mammalian protein found in Mus musculus

toll-like receptor 4
uniprot:Q9QUK6
Tlr4
lipopolysaccharide response
Toll like receptor 4

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUK6

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QUK6

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

12 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

WDFY1 mediates TLR3/4 signaling by recruiting TRIF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

An unusual dimeric structure and assembly for TLR4 regulator RP105–MD-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

transmembrane signaling receptor activity

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

lipopolysaccharide binding

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

lipopolysaccharide immune receptor activity

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

phosphatidylinositol 3-kinase binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

plasma membrane

determination method

lipopolysaccharide receptor complex

determination method

integral component of plasma membrane

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

plasma membrane

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

biological process

positive regulation of JNK cascade

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

cellular response to mechanical stimulus

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

I-kappaB phosphorylation

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of interleukin-6 production

determination method

8 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of tumor necrosis factor production

determination method

7 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

innate immune response

determination method

inflammatory response

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

negative regulation of interleukin-17 production

determination method

3 references

mast cell activation

determination method

3 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Toll-like receptor 4-mediated activation of murine mast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

toll-like receptor 4 signaling pathway

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of interleukin-10 production

determination method

3 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

immune system process

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

response to lipopolysaccharide

determination method

8 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of chemokine production

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

lipopolysaccharide-mediated signaling pathway

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of nitric oxide biosynthetic process

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

negative regulation of interleukin-6 production

determination method

3 references

MyD88-dependent toll-like receptor signaling pathway

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

positive regulation of gene expression

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

defense response to Gram-negative bacterium

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

macrophage activation

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

detection of lipopolysaccharide

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

cellular response to lipopolysaccharide

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

signal transduction

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

toll-like receptor signaling pathway

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

microglial cell activation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

innate immune response-activating signal transduction

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

leukotriene metabolic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

response to oxidative stress

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of gene expression

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

TRIF-dependent toll-like receptor signaling pathway

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of macrophage activation

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of DNA binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of nitric oxide biosynthetic process

determination method

response to ethanol

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

defense response to Gram-negative bacterium

determination method

3 references

8 April 2019

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

detection of temperature stimulus involved in sensory perception of pain

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

detection of mechanical stimulus involved in sensory perception of pain

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

regulation of sensory perception of pain

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

response to fatty acid

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

cellular response to lipopolysaccharide

determination method

8 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

9 May 2019

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

negative regulation of cold-induced thermogenesis

determination method

1 reference

9 May 2019

Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

cellular response to oxidised low-density lipoprotein particle stimulus

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of cytokine production involved in inflammatory response

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of oxidative stress-induced neuron death

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

positive regulation of reactive oxygen species biosynthetic process

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

MyD88-dependent toll-like receptor signaling pathway

determination method

1 reference

9 May 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QUK6

determination method

defense response to Gram-negative bacterium

determination method

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000102988

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000102988

ENSMUSP00000045770

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000045770

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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