(Q27678726)

GOA release 2020-03-11

Toll-like receptor 4

1 reference

GOA release 2020-03-11

author name string

Umeharu Ohto

1

0 references

Koichi Fukase

2

0 references

Kensuke Miyake

3

0 references

Toshiyuki Shimizu

Proceedings of the National Academy of Sciences of the United States of America

4

0 references

language of work or name

English

0 references

publication date

8 May 2012

0 references

published in

0 references

volume

109

0 references

issue

19

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page(s)

7421-6

0 references

cites work

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1 reference

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

20 March 2017

1 reference

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The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

20 March 2017

1 reference

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

20 March 2017

1 reference

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Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

20 March 2017

1 reference

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Lipid A modification systems in gram-negative bacteria

20 March 2017

1 reference

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Lipopolysaccharide endotoxins

20 March 2017

1 reference

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

20 March 2017

1 reference

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

20 March 2017

1 reference

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Innate immune recognition

20 March 2017

1 reference

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Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

20 March 2017

1 reference

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

20 March 2017

1 reference

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MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.

7 April 2017

1 reference

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MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation

29 September 2017

1 reference

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Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.

29 September 2017

1 reference

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Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin

29 September 2017

1 reference

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Structures of the toll-like receptor family and its ligand complexes

29 September 2017

1 reference

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Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.

29 September 2017

1 reference

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Structure and function of Toll receptors and their ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa.

29 September 2017

1 reference

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Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity

29 September 2017

1 reference

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Sepsis: still going strong

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

ML -- a conserved domain involved in innate immunity and lipid metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Human Toll-like receptor 4 recognizes host-specific LPS modifications.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Molecular mechanisms of endotoxin activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

The chemical structure of bacterial endotoxin in relation to bioactivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Bacterial endotoxin: molecular relationships of structure to activity and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Structural requirements of lipid A for endotoxicity and other biological activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Structure-activity relationship of chemically synthesized nonreducing parts of lipid A analogs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

Essential role of MD-2 in LPS responsiveness and TLR4 distribution.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358893

MD-2 binds to bacterial lipopolysaccharide

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22532668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Toll-like receptors and innate immunity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22532668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1201193109

1 reference

ADS bibcode

2012PNAS..109.7421O

0 references

1 reference

1 reference

PubMed publication ID

22532668

1 reference