(Q15321888)

http://www.ebi.ac.uk/interpro/protein/P22724

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transcription corepressor activity

1 reference

14 February 2019

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

signaling receptor binding

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

16 July 2018

Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

3 references

14 February 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Augmented Wnt signaling in a mammalian model of accelerated aging

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

receptor ligand activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

3 references

endoplasmic reticulum lumen

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

3 references

1 reference

14 February 2019

Wnt family proteins are secreted and associated with the cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

16 July 2018

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

Wnt family proteins are secreted and associated with the cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

non-canonical Wnt signaling pathway

IBA

biological process

1 reference

14 February 2019

The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

T cell differentiation in thymus

1 reference

14 February 2019

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of canonical Wnt signaling pathway

negative regulation of male gonad development

3 references

mesonephros development

1 reference

14 February 2019

Requirement of Lim1 for female reproductive tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

androgen biosynthetic process

1 reference

14 February 2019

Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of wound healing

1 reference

14 February 2019

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

cellular response to transforming growth factor beta stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of collagen biosynthetic process

3 references

mesonephric tubule development

1 reference

14 February 2019

vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

16 July 2018

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

mammary gland epithelium development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of cell differentiation

1 reference

14 February 2019

Wnt4 is required for proper male as well as female sexual development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

metanephric nephron morphogenesis

1 reference

14 February 2019

Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of apoptotic signaling pathway

1 reference

14 February 2019

WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

female sex determination

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

smooth muscle cell differentiation

negative regulation of gene expression

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis

female gonad development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of transcription, DNA-templated

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

A role for WNT proteins in induction of dermomyotome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of GTPase activity

1 reference

14 February 2019

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

Calcium/NFAT signalling promotes early nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

paramesonephric duct development

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Requirement of Lim1 for female reproductive tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

thyroid-stimulating hormone-secreting cell differentiation

1 reference

14 February 2019

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

hormone metabolic process

1 reference

14 February 2019

Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of steroid biosynthetic process

3 references

tertiary branching involved in mammary gland duct morphogenesis

1 reference

14 February 2019

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

Wnt4 is required for proper male as well as female sexual development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

male gonad development

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt4 is required for proper male as well as female sexual development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of aldosterone biosynthetic process

3 references

positive regulation of bone mineralization

3 references

anatomical structure development

1 reference

14 February 2019

Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

somatotropin secreting cell differentiation

1 reference

14 February 2019

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

metanephric mesenchymal cell differentiation

1 reference

14 February 2019

PAX2 activates WNT4 expression during mammalian kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

Female development in mammals is regulated by Wnt-4 signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

metanephric nephron development

1 reference

14 February 2019

Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of cell migration

1 reference

14 February 2019

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of osteoblast differentiation

3 references

renal vesicle formation

1 reference

14 February 2019

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

regulation of cell-cell adhesion

IBA

1 reference

14 February 2019

Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

epithelial to mesenchymal transition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

canonical Wnt signaling pathway

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of transcription, DNA-templated

5 references

14 February 2019

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

branching morphogenesis of an epithelial tube

1 reference

14 February 2019

Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

metanephric tubule formation

1 reference

14 February 2019

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

negative regulation of testosterone biosynthetic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

embryonic epithelial tube formation

1 reference

14 February 2019

Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of cortisol biosynthetic process

3 references

positive regulation of dermatome development

3 references

14 February 2019

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

cellular response to starvation

1 reference

14 February 2019

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

adrenal gland development

TAS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

multicellular organism development

negative regulation of fibroblast growth factor receptor signaling pathway

2 references

1 reference

14 February 2019

Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis

renal vesicle induction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of meiotic nuclear division

1 reference

14 February 2019

Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of focal adhesion assembly

1 reference

14 February 2019

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

immature T cell proliferation in thymus

1 reference

14 February 2019

The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

positive regulation of stress fiber assembly

1 reference

14 February 2019

Wnt4 inhibits cell motility induced by oncogenic Ras

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

protein localization to plasma membrane

TAS

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

21 June 2018

Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

negative regulation of canonical Wnt signaling pathway

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

21 June 2018

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

protein localization to plasma membrane

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

negative regulation of canonical Wnt signaling pathway

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

positive regulation of canonical Wnt signaling pathway

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

androgen biosynthetic process

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22724&geneProductId=UniProtKB:P22724

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22724

Wnt signaling pathway

IBA

negative regulation of androgen biosynthetic process

3 references

Wnt protein, conserved site

1 reference

stated in

InterPro Release 71.0