Wikidata

(Q15323263)

English

Period circadian clock 2

mammalian protein found in Mus musculus

  • period 2
  • period circadian protein homolog 2
  • period homolog 2
  • circadian clock protein PERIOD 2
  • Per2
In more languages

Statements

molecular function
protein binding
determination method
IPI
35 references
retrieved
5 June 2018
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
The polycomb group protein EZH2 is required for mammalian circadian clock function
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Biochemical analysis of the canonical model for the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Distinct roles of DBHS family members in the circadian transcriptional feedback loop
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
PML regulates PER2 nuclear localization and circadian function
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Casein kinase 1 delta regulates the pace of the mammalian circadian clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
A molecular mechanism for circadian clock negative feedback
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Molecular analysis of mammalian timeless
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Machine learning helps identify CHRONO as a circadian clock component
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
The BMAL1 C terminus regulates the circadian transcription feedback loop.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
cell component
nucleus
determination method
ISO
IDA
IEA
IPI
9 references
retrieved
5 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
ISO
retrieved
5 June 2018
stated in
Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IPI
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IEA
retrieved
5 June 2018
stated in
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
PML regulates PER2 nuclear localization and circadian function
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
biological process
circadian rhythm
determination method
IDA
IEP
5 references
retrieved
5 June 2018
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IEP
retrieved
5 June 2018
stated in
p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IEP
retrieved
5 June 2018
stated in
A role for Id2 in regulating photic entrainment of the mammalian circadian system
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IEP
retrieved
5 June 2018
stated in
ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IEP
retrieved
5 June 2018
stated in
Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
negative regulation of transcription, DNA-templated
determination method
IDA
ISO
6 references
retrieved
5 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
ISO
retrieved
5 June 2018
stated in
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
CIPC is a mammalian circadian clock protein without invertebrate homologues
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA
retrieved
5 June 2018
stated in
Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2
GOA
curator
UniProt
UniProt protein ID
O54943
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943
determination method
IDA

Identifiers

 
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