(Q2007868)

http://www.ebi.ac.uk/interpro/protein/P05112

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05112

Interleukin-4/interleukin-13, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

IL4 Crystal Structure recombinant.png
900 × 750; 214 KB

1 reference

imported from Wikimedia project

1 reference

13 November 2019

1 reference

interleukin-4 receptor binding

3 references

9 May 2019

The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

4 references

9 May 2019

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation

IPI

growth factor activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

cytokine receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

3 references

9 May 2019

The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of T cell differentiation

biological process

1 reference

9 May 2019

Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

dendritic cell differentiation

1 reference

9 May 2019

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

negative regulation of endothelial cell apoptotic process

1 reference

9 May 2019

IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

negative regulation of complement-dependent cytotoxicity

IMP

1 reference

9 May 2019

IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

regulation of phosphorylation

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

negative regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

myeloid dendritic cell differentiation

1 reference

9 May 2019

Galectin-9 induces maturation of human monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

Inflammatory cytokines (IL-4, IL-5 and IL-13)

type 2 immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of interleukin-13 production

1 reference

9 May 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation

B cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

T-helper 2 cell cytokine production

TAS

1 reference

9 May 2019

Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

regulation of isotype switching

1 reference

9 May 2019

The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

negative regulation of transcription, DNA-templated

TAS

negative regulation of epithelial cell migration

1 reference

9 May 2019

Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

cholesterol metabolic process

1 reference

9 May 2019

Interleukin-4 deficiency promotes gallstone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of B cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of T cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

1 reference

9 May 2019

CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of MHC class II biosynthetic process

IGI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

negative regulation of osteoclast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of transcription, DNA-templated

3 references

9 May 2019

LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

9 May 2019

Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of isotype switching to IgE isotypes

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of isotype switching to IgG isotypes

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

regulation of immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

cytokine-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of macroautophagy

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

activation of Janus kinase activity

IGI

1 reference

9 May 2019

Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of receptor-mediated endocytosis

IGI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

negative regulation of neuroinflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of amyloid-beta clearance

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

neuroinflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of cellular respiration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

positive regulation of ATP biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112

Interleukin-4/interleukin-13, conserved site

Gene Atlas image

PBB GE IL4 207539 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05112

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

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9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016