(Q24310081)

2

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Jana Vaclavikova

3

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Leremy A Colf

4

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Xiulan Qi

5

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Nicola M Heller

6

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Achsah D Keegan

7

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K Christopher Garcia

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

8

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language of work or name

English

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publication date

25 January 2008

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published in

Cell

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volume

132

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issue

2

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page(s)

259-72

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cites work

1 reference

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Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

19 March 2017

1 reference

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Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

19 March 2017

1 reference

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

19 March 2017

1 reference

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Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans

19 March 2017

1 reference

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Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130

19 March 2017

1 reference

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Solution structure of human IL-13 and implication for receptor binding

19 March 2017

1 reference

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An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

19 March 2017

1 reference

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Crystal structure of recombinant human interleukin-4

19 March 2017

1 reference

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Solving structures of protein complexes by molecular replacement with Phaser

19 March 2017

1 reference

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Coot: model-building tools for molecular graphics

19 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

19 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

19 March 2017

1 reference

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An approach to multi-copy search in molecular replacement

19 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

19 March 2017

1 reference

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Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

19 March 2017

2 references

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19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Characterization of the interaction between interleukin-13 and interleukin-13 receptors

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Kinetic analysis of the interleukin-13 receptor complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

The IL-4 receptor: signaling mechanisms and biologic functions

19 March 2017

1 reference

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The prolactin receptor rescues EpoR-/- erythroid progenitors and replaces EpoR in a synergistic interaction with c-kit

19 March 2017

1 reference

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cDNA cloning and characterization of the human interleukin 13 receptor alpha chain

19 March 2017

1 reference

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The immunoglobulin fold. Structural classification, sequence patterns and common core

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Structural design and molecular evolution of a cytokine receptor superfamily

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor

27 September 2017

1 reference

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Mechanistic diversity of cytokine receptor signaling across cell membranes

27 September 2017

1 reference

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Interleukin-13 in asthma pathogenesis

27 September 2017

1 reference

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Molecular phylogeny within type I cytokines and their cognate receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Structure, binding, and antagonists in the IL-4/IL-13 receptor system.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Cytokine and cytokine receptor pleiotropy and redundancy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Cytokine modulators as novel therapies for asthma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Acquisition of lymphokine-producing phenotype by CD4+ T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Sharing of a common gamma chain, gamma c, by the IL-2, IL-4, and IL-7 receptors: implications for X-linked severe combined immunodeficiency (XSCID).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Characterization of the human B cell stimulatory factor 1 receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Interleukin-4 and interleukin-13 signaling connections maps

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

Interleukin-13 receptor alpha' but not alpha chain: a functional component of interleukin-4 receptors

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265076

The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters

29 November 2018

1 reference

12 December 2020

Functional epitope of common gamma chain for interleukin-4 binding

1 reference

12 December 2020

Crystal structure of human recombinant interleukin-4 at 2.25 A resolution

1 reference

12 December 2020

The structure of interleukin-2 complexed with its alpha receptor

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

The Immunoglobulin Fold

1 reference

12 December 2020

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.12.030

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.CELL.2007.12.030

1 reference

1 reference

1 reference

PubMed publication ID

18243101

1 reference