(Q21092482)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

title

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

0 references

0 references

1 reference

1

Heather M O'Hagan

Heather M

O'Hagan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

3

Stephen B Baylin

Stephen B

Baylin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Helai P Mohammad

2

Helai P

Mohammad

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

language of work or name

English

0 references

publication date

15 August 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

page(s)

e1000155

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

12 January 2020

copyright license

start time

15 August 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

1 reference

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DNA damage, homology-directed repair, and DNA methylation

19 March 2017

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SIRT1 promotes DNA repair activity and deacetylation of Ku70

19 March 2017

1 reference

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Phosphorylation of HuR by Chk2 regulates SIRT1 expression

19 March 2017

1 reference

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

19 March 2017

1 reference

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The Polycomb group protein EZH2 directly controls DNA methylation

19 March 2017

1 reference

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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

19 March 2017

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

19 March 2017

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

19 March 2017

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Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

19 March 2017

1 reference

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

19 March 2017

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Histone deacetylases (HDACs): characterization of the classical HDAC family

19 March 2017

1 reference

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

19 March 2017

1 reference

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

19 March 2017

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

19 March 2017

1 reference

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Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

19 March 2017

1 reference

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

19 March 2017

1 reference

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

19 March 2017

1 reference

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

19 March 2017

1 reference

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

19 March 2017

1 reference

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Translating the Histone Code

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

The language of covalent histone modifications

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair

19 March 2017

1 reference

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Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Genome maintenance mechanisms for preventing cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Regulation of DNA double-strand break repair pathway choice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

De novo CpG island methylation in human cancer cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone acetyltransferases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone H4-K16 acetylation controls chromatin structure and protein interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

The epigenetic progenitor origin of human cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Epigenetic stem cell signature in cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

A functional link between SIRT1 deacetylase and NBS1 in DNA damage response

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Global chromatin compaction limits the strength of the DNA damage response

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone modifications in response to DNA damage.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Recruitment of DNA methyltransferase I to DNA repair sites

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Mutagenicity, toxicity and repair of DNA base damage induced by oxidation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

When repair meets chromatin. First in series on chromatin dynamics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Nucleosome rearrangement in human chromatin during UV-induced DNA- reapir synthesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

LSH cooperates with DNA methyltransferases to repress transcription

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Inhibition of transcription at radiation-induced nuclear foci of phosphorylated histone H2AX in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Chromatin dynamics during DSB repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Molecular model for telomeric heterochromatin in yeast

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Double-strand break repair mediated by DNA end-joining.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000155

Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000155

Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000155

Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491723

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

29 November 2018

2 references

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000155

21 January 2018

12 December 2020

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas

1 reference

12 December 2020

The cellular response to DNA double-strand breaks: defining the sensors and mediators

1 reference

12 December 2020

The host defence function of genomic methylation patterns

1 reference

12 December 2020

Recombination and joining: different means to the same ends

1 reference

12 December 2020

Telomeres--unsticky ends

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1000155

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18704159%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

2 references