(Q21100639)

English

CD274 molecule

mammalian protein found in Homo sapiens

B7 homolog 1
B7-H1 Antigen
PDCD1 ligand 1
B7-H1
programmed cell death 1 ligand 1
CD274
CD274 antigen
PD-L1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

0 references

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZQ7

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NZQ7

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD80-like, immunoglobulin C2-set, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

6 references

8 April 2019

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Interaction of human PD-L1 and B7-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

external side of plasma membrane

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

endomembrane system

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

early endosome membrane

determination method

1 reference

24 April 2018

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

recycling endosome membrane

determination method

1 reference

24 April 2018

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

biological process

negative regulation of interleukin-10 production

determination method

response to cytokine

determination method

1 reference

8 April 2019

Porcine PD-L1: cloning, characterization, and implications during xenotransplantation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

negative regulation of interferon-gamma production

determination method

negative regulation of tumor necrosis factor superfamily cytokine production

determination method

1 reference

8 April 2019

PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

positive regulation of cell migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

toxin transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

negative regulation of activated T cell proliferation

determination method

1 reference

8 April 2019

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

cell surface receptor signaling pathway

determination method

1 reference

16 July 2018

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

negative regulation of T cell proliferation

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

regulation of T cell apoptotic process

determination method

1 reference

8 April 2019

Human renal tubular epithelial cells suppress alloreactive T cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

immune response

determination method

1 reference

16 July 2018

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

signal transduction

determination method

1 reference

16 July 2018

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZQ7&geneProductId=UniProtKB:Q9NZQ7

determination method

regulation of activated CD4-positive, alpha-beta T cell apoptotic process

determination method

1 reference

8 April 2019

PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process

determination method

1 reference

8 April 2019

PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

negative regulation of CD4-positive, alpha-beta T cell proliferation

determination method

1 reference

8 April 2019

VISTA is an immune checkpoint molecule for human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

T cell costimulation

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

positive regulation of T cell proliferation

determination method

3 references

8 April 2019

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

cellular response to lipopolysaccharide

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

adaptive immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZQ7

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301587

Identifiers

MeSH descriptor ID

subject named as

B7-H1 Antigen

An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION. (English)

0 references

D12.776.467.150.300

0 references

D12.776.543.095.300

0 references

D23.050.301.285.400

0 references

D23.529.168.300

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000370985

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370985

ENSP00000370989

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370989

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(10 entries)

dewiki Programmed Cell Death 1 Ligand 1
enwiki PD-L1
eswiki PD-L1
fawiki PD-L1
frwiki PD-L1
jawiki PD-L1
kowiki PD-L1
ruwiki CD274
ukwiki CD274
zhwiki 細胞程式死亡-配體1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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