(Q21102539)

English

DEP domain containing 5, GATOR1 subcomplex subunit

mammalian protein found in Homo sapiens

DEPDC5
DEP domain containing 5
GATOR complex protein DEPDC5
DEP domain-containing protein 5

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Statements

1 reference

13 November 2019

winged helix DNA-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75140

Winged helix-like DNA-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75140

Vacuolar membrane-associated protein Iml1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75140

DEP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein-containing complex binding

determination method or standard

IDA

GTPase activator activity

determination method or standard

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IEA

retrieved

9 May 2019

stated in

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IBA

cell component

cytoplasm

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IEA

GATOR1 complex

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IDA

lysosomal membrane

determination method or standard

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IEA

retrieved

26 September 2017

stated in

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IDA

retrieved

26 September 2017

stated in

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IDA

membrane

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IEA

lysosomal membrane

determination method or standard

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IEA

retrieved

9 May 2019

stated in

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IBA

retrieved

9 May 2019

stated in

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

HDA

Cul3-RING ubiquitin ligase complex

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IDA

biological process

negative regulation of TOR signaling

determination method or standard

IMP

1 reference

retrieved

26 September 2017

stated in

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IMP

cellular response to amino acid starvation

determination method or standard

IMP

1 reference

retrieved

26 September 2017

stated in

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IMP

intracellular signal transduction

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IEA

positive regulation of GTPase activity

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75140

determination method or standard

IEA

negative regulation of TORC1 signaling

determination method or standard

IMP

regulation of autophagy

determination method or standard

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75140&geneProductId=UniProtKB:O75140

determination method or standard

IBA

cellular response to amino acid starvation

determination method or standard

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75140

Identifiers

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13 November 2019

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(Q21102539)

DEP domain containing 5, GATOR1 subcomplex subunit

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