(Q59085556)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

26 March 2020

main subject

1 reference

DEP domain containing 5, GATOR1 subcomplex subunit

1 reference

Kelch like family member 22

1 reference

Protein maternal effect lethal 26 CELE_ZK858.4

1 reference

author name string

Jie Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Yuhui Ou

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Yanyan Yang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Wen Li

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Ye Xu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Yuntao Xie

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Ying Liu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

language of work or name

English

0 references

publication date

16 May 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

number of pages

5

1 reference

inferred from page(s)

published in

Nature

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

volume

557

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

issue

7706

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

page(s)

585-589

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29769719%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/s41586-018-0128-9

26 March 2020

exact match

0 references

cites work

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Nutrient sensing, metabolism, and cell growth control

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Regulation of TORC1 by Rag GTPases in nutrient response

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7 January 2021

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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7 January 2021

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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7 January 2021

mTOR and cancer: insights into a complex relationship

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Defining the role of mTOR in cancer

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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

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Proteogenomics connects somatic mutations to signalling in breast cancer

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7 January 2021

Function and regulation of cullin-RING ubiquitin ligases

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7 January 2021

Update on the Kelch-like (KLHL) gene family

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7 January 2021

Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.

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7 January 2021

Ubiquitylation-dependent localization of PLK1 in mitosis

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7 January 2021

Identification, analysis, and prediction of protein ubiquitination sites

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7 January 2021

A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles

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7 January 2021

SZT2 dictates GATOR control of mTORC1 signalling.

1 reference

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7 January 2021

Metabolism. Differential regulation of mTORC1 by leucine and glutamine

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7 January 2021

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

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7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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7 January 2021

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

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7 January 2021

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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7 January 2021

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

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7 January 2021

Genetics: influence of TOR kinase on lifespan in C. elegans

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7 January 2021

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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7 January 2021

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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7 January 2021

Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C.

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7 January 2021

Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis

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7 January 2021