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Nutrient sensing, metabolism, and cell growth control
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PubMed
title
Nutrient sensing, metabolism, and cell growth control
(English)
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main subject
cell growth
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based on heuristic
inferred from title
author name string
Hai-Xin Yuan
series ordinal
1
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Crossref
Yue Xiong
series ordinal
2
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Crossref
Kun-Liang Guan
series ordinal
3
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language of work or name
English
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stated in
PubMed
publication date
7 February 2013
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stated in
PubMed
published in
Molecular Cell
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stated in
PubMed
volume
49
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stated in
PubMed
issue
3
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stated in
PubMed
page(s)
379-87
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PubMed
cites work
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
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PubMed Central
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SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling
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PubMed Central
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21 March 2017
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
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PubMed Central
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21 March 2017
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
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PubMed Central
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21 March 2017
Structure of mammalian AMPK and its regulation by ADP
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PubMed Central
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21 March 2017
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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PubMed Central
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21 March 2017
Hypoxia-inducible factors and the response to hypoxic stress
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PubMed Central
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21 March 2017
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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PubMed Central
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21 March 2017
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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PubMed Central
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21 March 2017
Understanding the Warburg effect: the metabolic requirements of cell proliferation
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PubMed Central
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21 March 2017
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
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PubMed Central
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21 March 2017
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
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PubMed Central
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21 March 2017
AMPK and PPARdelta agonists are exercise mimetics
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PubMed Central
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21 March 2017
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
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21 March 2017
AMPK phosphorylation of raptor mediates a metabolic checkpoint
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PubMed Central
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21 March 2017
Brick by brick: metabolism and tumor cell growth
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PubMed Central
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21 March 2017
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
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PubMed Central
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21 March 2017
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
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PubMed Central
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21 March 2017
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
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Regulation of mTOR and cell growth in response to energy stress by REDD1.
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21 March 2017
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
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PubMed Central
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21 March 2017
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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PubMed Central
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21 March 2017
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587157
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21 March 2017
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
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21 March 2017
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
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21 March 2017
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
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PubMed Central
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21 March 2017
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
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21 March 2017
TSC2 mediates cellular energy response to control cell growth and survival
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PubMed Central
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21 March 2017
Leucyl-tRNA synthetase controls TORC1 via the EGO complex
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21 March 2017
The Vam6 GEF controls TORC1 by activating the EGO complex
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21 March 2017
Histone demethylation by a family of JmjC domain-containing proteins
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21 March 2017
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
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PubMed Central
reference URL
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21 March 2017
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
1 reference
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PubMed Central
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21 March 2017
Different modes of activating phosphofructokinase, a key regulatory enzyme of glycolysis, in working vertebrate muscle
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21 March 2017
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
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21 March 2017
Inhibition of 2-oxoglutarate dependent oxygenases
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PubMed Central
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21 March 2017
Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases
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21 March 2017
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
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21 March 2017
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
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21 March 2017
The AMP-activated protein kinase cascade--a unifying system for energy control
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21 March 2017
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
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21 March 2017
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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21 March 2017
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
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21 March 2017
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
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21 March 2017
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
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21 March 2017
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
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21 March 2017
Autophagy: renovation of cells and tissues
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7 April 2017
The role of Atg proteins in autophagosome formation
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7 April 2017
Regulation mechanisms and signaling pathways of autophagy
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7 April 2017
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
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PubMed Central
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7 April 2017
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
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7 April 2017
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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7 April 2017
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
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7 April 2017
Termination of autophagy and reformation of lysosomes regulated by mTOR
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7 April 2017
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
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PubMed Central
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7 April 2017
Molecular mechanisms of mTOR-mediated translational control
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7 April 2017
Regulation of TORC1 by Rag GTPases in nutrient response
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7 April 2017
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
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7 April 2017
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
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7 April 2017
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
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7 April 2017
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
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7 April 2017
Coping with stress: eIF2 kinases and translational control
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7 April 2017
Translational regulation of GCN4 and the general amino acid control of yeast
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7 April 2017
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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7 April 2017
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
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7 April 2017
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
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PubMed Central
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28 September 2017
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
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28 September 2017
A unifying model for mTORC1-mediated regulation of mRNA translation.
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28 September 2017
Alterations of metabolic genes and metabolites in cancer
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28 September 2017
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
1 reference
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PubMed Central
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28 September 2017
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer
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28 September 2017
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
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28 September 2017
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
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28 September 2017
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
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28 September 2017
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
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28 September 2017
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming
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28 September 2017
TOR-dependent control of autophagy: biting the hand that feeds
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28 September 2017
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway
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PubMed Central
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28 September 2017
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
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PubMed Central
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28 September 2017
Hypoxia signalling through mTOR and the unfolded protein response in cancer
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PubMed Central
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28 September 2017
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
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PubMed Central
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28 September 2017
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
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PubMed Central
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28 September 2017
ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587157
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28 September 2017
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.
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28 September 2017
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
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PubMed Central
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28 September 2017
regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587157
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28 September 2017
Rheb promotes cell growth as a component of the insulin/TOR signalling network
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587157
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28 September 2017
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
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PubMed Central
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28 September 2017
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
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PubMed Central
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28 September 2017
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
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31 May 2018
AMPK is a direct adenylate charge-regulated protein kinase.
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PubMed Central
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28 November 2018
The interplay between MYC and HIF in cancer.
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28 November 2018
AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis
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PubMed Central
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28 November 2018
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587157
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28 November 2018
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
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PubMed Central
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28 November 2018
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/23395268
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23395268
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23395268
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.MOLCEL.2013.01.019
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4188178
OpenCitations bibliographic resource ID
4188178
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4188178
PMC publication ID
3587157
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4188178
PubMed publication ID
23395268
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4188178
ResearchGate publication ID
235440717
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