Wikidata

(Q21109282)

English

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

mammalian protein found in Homo sapiens

  • tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
  • epididymis luminal protein 2
  • protein kinase C inhibitor protein-1
  • 14-3-3 protein epsilon
  • mitochondrial import stimulation factor L subunit
  • 14-3-3 epsilon
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • YWHAE
In more languages

Statements

molecular function
protein binding
determination method
IPI
51 references
stated in
UniProt
UniProt protein ID
P62258
retrieved
4 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Phosphorylation of grb10 regulates its interaction with 14-3-3
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Anti-brain antibodies in serum and cerebrospinal fluid following cranio-cerebral trauma
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1
GOA
curator
UniProt
UniProt protein ID
P62258
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Rapid identification of 14-3-3-binding proteins by protein microarray analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Differential localization of HDAC4 orchestrates muscle differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for protein-protein interactions in the 14-3-3 protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
AMPK modulates Hippo pathway activity to regulate energy homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights of the MLF1/14-3-3 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 proteins associate with cdc25 phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3ε
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
PP2A regulates HDAC4 nuclear import
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
retrieved
8 April 2019
stated in
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62258
determination method
IPI
cell component
biological process

Identifiers

 
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