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Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
scientific journal article
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
title
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
(English)
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
main subject
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
1 reference
stated in
GOA release 2020-03-11
Heat shock protein 90 alpha family class A member 1
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase kinase 1
1 reference
stated in
GOA release 2020-03-11
Cell division cycle 37, HSP90 cochaperone
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase kinase 2
1 reference
stated in
GOA release 2020-03-11
scaffold protein binding
1 reference
stated in
GOA release 2020-03-11
Kinase suppressor of ras 1
1 reference
stated in
GOA release 2020-03-11
Dual specificity mitogen-activated protein kinase kinase mek-2 CELE_Y54E10BL.6
1 reference
stated in
GOA release 2020-03-11
Ras protein let-60 CELE_ZK792.6
1 reference
stated in
GOA release 2020-03-11
Kinase suppressor of Ras A CELE_F13B9.5
1 reference
stated in
GOA release 2020-03-11
author name string
S. Stewart
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
M. Sundaram
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
Y. Zhang
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
J. Lee
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
M. Han
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
K. L. Guan
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
language of work or name
English
0 references
publication date
1 August 1999
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
published in
Molecular and Cellular Biology
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
volume
19
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
issue
8
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stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
page(s)
5523–5534
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stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
cites work
A mammalian scaffold complex that selectively mediates MAP kinase activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
Cdc37 is a molecular chaperone with specific functions in signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
Kinase suppressor of Ras is ceramide-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
KSR modulates signal propagation within the MAPK cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
KSR, a novel protein kinase required for RAS signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
Mammalian Ras interacts directly with the serine/threonine kinase Raf
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
Activation of ternary complex factor Elk-1 by MAP kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
p21 is a universal inhibitor of cyclin kinases
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PubMed Central
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17 March 2017
Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Cytoplasmic localization of the mitogen-activated protein kinase activator MEK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
17 March 2017
Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
The genetics of Caenorhabditis elegans
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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17 March 2017
Mitogen-activated protein kinase pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
7 April 2017
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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7 April 2017
KSR stimulates Raf-1 activity in a kinase-independent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
29 September 2017
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
Signal transduction from multiple Ras effectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
Receptor protein-tyrosine kinases and their signal transduction pathways
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
Transcriptional regulation by extracellular signals: mechanisms and specificity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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29 September 2017
The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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3 June 2018
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
3 June 2018
The protein kinase KSR interacts with 14-3-3 protein and Raf.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
3 June 2018
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
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3 June 2018
The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
27 November 2018
Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
27 November 2018
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
27 November 2018
Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
27 November 2018
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84397
retrieved
27 November 2018
Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10409742
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10409742
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.19.8.5523
0 references
PMCID
84397
0 references
PubMed ID
10409742
1 reference
stated in
PubMed
PubMed ID
10409742
retrieved
3 February 2017
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