Wikidata

(Q21100360)

English

Mitogen-activated protein kinase kinase 1

mammalian protein found in Homo sapiens

  • ERK activator kinase 1
  • protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
  • MAP2K1
  • MEK 1
  • MAPK/ERK kinase 1
  • MAPKK 1
  • dual specificity mitogen-activated protein kinase kinase 1
  • MAP Kinase Kinase 1
In more languages

Statements

molecular function
protein binding
determination method
IPI
20 references
retrieved
8 April 2019
stated in
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
GOA
curator
UniProt
UniProt protein ID
Q02750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Spatial regulation of Raf kinase signaling by RKTG
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of human myoblast differentiation by PEBP4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Mxi2 promotes stimulus-independent ERK nuclear translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
retrieved
8 April 2019
stated in
Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02750
determination method
IPI
cell component
biological process
physically interacts with

Identifiers

MeSH descriptor ID
D048369
subject named as
MAP Kinase Kinase 1
0 references
PDB structure ID
 
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