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The ERK signaling cascade--views from different subcellular compartments
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instance of
scholarly article
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review article
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stated in
Europe PubMed Central
title
The ERK signaling cascade--views from different subcellular compartments
(English)
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main subject
clinical chemistry
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Mitogen-activated protein kinase kinase 1
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase kinase 2
1 reference
stated in
GOA release 2020-03-11
ERT2
1 reference
stated in
GOA release 2020-03-11
mitogen-activated protein kinase 1
1 reference
stated in
GOA release 2020-03-11
regulation of early endosome to late endosome transport
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase 3
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase 1
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase kinase 2
1 reference
stated in
GOA release 2020-03-11
Mitogen-activated protein kinase kinase 1
1 reference
stated in
GOA release 2020-03-11
author name string
Zhong Yao
series ordinal
1
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Rony Seger
series ordinal
2
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language of work or name
English
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publication date
2009
1 reference
stated in
PubMed
published in
BioFactors
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volume
35
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issue
5
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page(s)
407-16
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cites work
KSR, a novel protein kinase required for RAS signal transduction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
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inferred from DOI database lookup
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
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7 January 2021
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inferred from DOI database lookup
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MEK/ERK cascade: from signaling specificity to diverse functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sef is a spatial regulator for Ras/MAP kinase signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of a general nuclear translocation signal in signaling proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 targets the protein kinase Raf-1 to mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CNK, a RAF-binding multidomain protein required for RAS signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Docking domains and substrate-specificity determination for MAP kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activated MEK1 binds the nuclear MyoD transcriptional complex to repress transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensing the environment: a historical perspective on integrin signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RAF proteins take centre stage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RSK family of kinases: emerging roles in cellular signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signalling to translation: how signal transduction pathways control the protein synthetic machinery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IQGAP1 modulates activation of B-Raf
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spatial regulation of Raf kinase signaling by RKTG
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of mitogen-activated protein kinase with the microtubule cytoskeleton
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a cytoplasmic-retention sequence in ERK2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the activation loop of ERK in the detachment from cytosolic anchoring
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in ERK2 Binding Sites Affect Nuclear Entry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isoform-specific interaction of C-RAF with mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Raf-1 activation and signalling by dephosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear localization and regulation of erk- and rsk-encoded protein kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isoform-specific localization of A-RAF in mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation and role of Raf-1/B-Raf heterodimerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein-protein interactions in the regulation of the extracellular signal-regulated kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FBIOF.52
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/BIOF.52
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PubMed publication ID
19565474
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