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Bcl-2 targets the protein kinase Raf-1 to mitochondria
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title
Bcl-2 targets the protein kinase Raf-1 to mitochondria
(English)
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main subject
Raf-1 proto-oncogene, serine/threonine kinase
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stated in
GOA release 2020-03-11
apoptotic process
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stated in
GOA release 2020-03-11
mitochondrion
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based on heuristic
inferred from title
author
Hong-Gang Wang
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stated in
ORCID Public Data File 2021
author name string
H G Wang
series ordinal
1
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U R Rapp
series ordinal
2
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J C Reed
series ordinal
3
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language of work or name
English
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publication date
15 November 1996
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published in
Cell
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volume
87
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page(s)
629-38
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issue
4
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cites work
Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Diminished cell proliferation associated with the death-protective activity of Bcl-2
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ins and outs of Raf kinases
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correlation of two-hybrid affinity data with in vitro measurements
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
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inferred from DOI database lookup
Molecular glue: kinase anchoring and scaffold proteins
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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A biochemical function for ras--at last
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
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Crossref
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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Functional dissection of the human Bc12 protein: sequence requirements for inhibition of apoptosis
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Crossref
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Raf-1 activates MAP kinase-kinase
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
Checkpoints of dueling dimers foil death wishes
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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inferred from DOI database lookup
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
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Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Raf as a result of recruitment to the plasma membrane
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive expression of the machinery for programmed cell death
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial control of nuclear apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981383-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0092-8674(00)81383-5
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
962953
OpenCitations bibliographic resource ID
962953
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
962953
PubMed ID
8929532
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
962953
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