(Q46331610)

21 December 2017

title

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. (English)

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21 December 2017

2

W J Fantl

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21 December 2017

Lewis T. Williams

series ordinal

4

object named as

L T Williams

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21 December 2017

author name string

W Yu

series ordinal

1

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21 December 2017

G Harrowe

series ordinal

3

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21 December 2017

language of work or name

English

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publication date

1 January 1998

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21 December 2017

published in

Current Biology

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21 December 2017

volume

8

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21 December 2017

page(s)

56-64

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21 December 2017

issue

1

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21 December 2017

https://api.crossref.org/works/10.1016%2FS0960-9822%2898%2970020-X

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Signalling pathways: jack of all cascades

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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The ras gene family and human carcinogenesis

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New molecular targets for cancer therapy.

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KSR, a novel protein kinase required for RAS signal transduction

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7 January 2021

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

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The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1 reference

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KSR: a novel player in the RAS pathway

1 reference

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7 January 2021

KSR modulates signal propagation within the MAPK cascade

1 reference

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A novel genetic system to detect protein-protein interactions

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The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest

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Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system

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The protein kinase KSR interacts with 14-3-3 protein and Raf.

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Kinase suppressor of Ras is ceramide-activated protein kinase

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.

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Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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Complex formation between RAS and RAF and other protein kinases

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The mitogen-activated protein kinase activator

1 reference

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Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

1 reference

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7 January 2021

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

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Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1.

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

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7 January 2021

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

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7 January 2021

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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7 January 2021

Immunological characterization of avian MAP kinases: evidence for nuclear localization

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7 January 2021

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

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7 January 2021

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

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Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1 reference

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Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

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Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

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7 January 2021

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

1 reference

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7 January 2021

Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase

1 reference

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7 January 2021

Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein

1 reference

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7 January 2021

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

1 reference

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7 January 2021

Activation of the MAP kinase pathway by the protein kinase raf

1 reference

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7 January 2021

Raf-1 activates MAP kinase-kinase

1 reference

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7 January 2021

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2898%2970020-X

7 January 2021

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

1 reference

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7 January 2021

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1 reference

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7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

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7 January 2021

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

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7 January 2021

10.1016/S0960-9822(98)70020-X

Identifiers

DOI

1 reference

21 December 2017

PubMed ID

9427629

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21 December 2017