Wikidata

(Q21104817)

English

Erb-b2 receptor tyrosine kinase 4

mammalian protein found in Homo sapiens

  • proto-oncogene-like protein c-ErbB-4
  • avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
  • receptor tyrosine-protein kinase erbB-4
  • ERBB4 transcript variant I20DEL
  • p180erbB4
  • tyrosine kinase-type cell surface receptor HER4
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
  • ERBB4 transcript variant I12DEL
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4
  • human epidermal growth factor receptor 4
  • ERBB4
  • Receptor, ErbB-4
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
16 references
retrieved
8 April 2019
stated in
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4
GOA
curator
UniProt
UniProt protein ID
Q15303
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
GOA
curator
UniProt
UniProt protein ID
Q15303
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer
GOA
curator
UniProt
UniProt protein ID
Q15303
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels
GOA
curator
UniProt
UniProt protein ID
Q15303
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways
GOA
curator
UniProt
UniProt protein ID
Q15303
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D066247
subject named as
Receptor, ErbB-4
0 references
 
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