(Q21105099)

http://www.ebi.ac.uk/interpro/protein/Q99684

Zinc finger C2H2 superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99684

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

DNA-binding transcription repressor activity, RNA polymerase II-specific

2 references

10 September 2018

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99684&geneProductId=UniProtKB:Q99684

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

13 references

8 April 2019

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

DNA-binding transcription factor activity

ISA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

transcription repressor complex

2 references

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

positive regulation of interleukin-6-mediated signaling pathway

IBA

biological process

1 reference

8 April 2019

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

negative regulation of neuron projection development

1 reference

8 April 2019

Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

regulation of toll-like receptor signaling pathway

1 reference

8 April 2019

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

regulation of histone H3-K4 methylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

negative regulation of transcription by RNA polymerase II

2 references

27 March 2018

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99684&geneProductId=UniProtKB:Q99684

27 March 2018

Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99684&geneProductId=UniProtKB:Q99684

regulation of transcription involved in G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

transcription, DNA-templated

TAS

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99684&geneProductId=UniProtKB:Q99684

negative regulation of vitamin D biosynthetic process

1 reference

8 April 2019

Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

negative regulation of calcidiol 1-monooxygenase activity

IC

1 reference

8 April 2019

Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

negative regulation of transcription, DNA-templated

TAS

1 reference

8 April 2019

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

negative regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

cellular response to lipopolysaccharide

ISS

1 reference

8 April 2019

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

negative regulation of transcription by RNA polymerase II

3 references

8 April 2019

Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

positive regulation of transcription by RNA polymerase II

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99684

IBA

has part(s)

Zinc finger C2H2-type

1 reference

stated in

InterPro Release 71.0